Merkel cell polyomavirus infection, large T antigen, retinoblastoma protein and outcome in Merkel cell carcinoma

H Sihto, H Kukko, V Koljonen, R Sankila, T Böhling… - Clinical Cancer …, 2011 - AACR
Purpose: Merkel cell carcinoma (MCC) is rare skin cancer that is often associated with
Merkel cell polyomavirus (MCPyV) infection. Polyomaviruses repress tumor suppressor …

Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma

H Sihto, H Kukko, V Koljonen, R Sankila… - JNCI: Journal of the …, 2009 - academic.oup.com
Background Merkel cell carcinoma is a rare malignancy of the skin. Integration of Merkel cell
polyomavirus (MCPyV) DNA to the tumor genome is frequent in these cancers. The clinical …

Merkel cell polyomavirus and non‐Merkel cell carcinomas: guilty or circumstantial evidence?

B Csoboz, K Rasheed, B Sveinbjørnsson, U Moens - Apmis, 2020 - Wiley Online Library
Merkel cell polyomavirus (MCPyV) is the major causative factor of the rare but aggressive
cancer, Merkel cell carcinoma (MCC). Two characteristics of MCPyV‐positive MCCs are …

Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR‐alpha and survival in Merkel cell carcinoma

M Waltari, H Sihto, H Kukko, V Koljonen… - … Journal of Cancer, 2011 - Wiley Online Library
Abstract Most Merkel cell carcinomas (MCCs) contain Merkel cell polyomavirus (MCPyV)
DNA, and the virus likely has a pivotal role in tumor pathogenesis. p53 and the KIT receptor …

Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression

K Bhatia, JJ Goedert, R Modali… - … journal of cancer, 2010 - Wiley Online Library
Merkel cell polyomavirus (MCPyV) was recently discovered in Merkel cell carcinoma (MCC),
a clinically and pathologically heterogeneous malignancy of dermal neuroendocrine cells …

[HTML][HTML] Merkel cell polyomavirus status is not associated with clinical course of Merkel cell carcinoma

D Schrama, WK Peitsch, M Zapatka, H Kneitz… - Journal of Investigative …, 2011 - Elsevier
The majority of Merkel cell carcinomas (MCCs) are associated with the recently identified
Merkel cell polyomavirus (MCV). However, as it is still unclear to which extent the presence …

Epidemiology of Merkel cell polyomavirus infection and Merkel cell carcinoma

S Silling, A Kreuter, T Gambichler, T Meyer… - Cancers, 2022 - mdpi.com
Simple Summary Merkel cell polyomavirus (MCPyV) is a widespread virus that is present on
human skin. Infection occurs early in life, and up to 90% of adults have antibodies against …

Usefulness of significant morphologic characteristics in distinguishing between Merkel cell polyomavirus–positive and Merkel cell polyomavirus–negative Merkel cell …

T Iwasaki, M Matsushita, S Kuwamoto, M Kato… - Human Pathology, 2013 - Elsevier
Merkel cell polyomavirus (MCPyV) monoclonally integrates into genomes of approximately
80% of Merkel cell carcinomas (MCCs) and undergoes mutation. We previously …

Presence of Merkel cell polyomavirus in Japanese cutaneous squamous cell carcinoma

M Murakami, M Imajoh, T Ikawa, H Nakajima… - Journal of Clinical …, 2011 - Elsevier
BACKGROUND: Merkel cell polyomavirus (MCPyV) was first identified in Merkel cell
carcinoma (MCC) as a new tumor virus. Studies have also reported differing frequencies of …

[HTML][HTML] Immunological detection of viral large T antigen identifies a subset of Merkel cell carcinoma tumors with higher viral abundance and better clinical outcome

K Bhatia, JJ Goedert, R Modali, L Preiss… - International journal of …, 2010 - ncbi.nlm.nih.gov
MCPyV, a new human oncogenic polyoma virus, appears etiologic for the classic, rare,
aggressive Merkel Cell Carcinomas (MCC) of the skin characterized by MCPyV DNA …