[HTML][HTML] GPR4 deficiency alleviates intestinal inflammation in a mouse model of acute experimental colitis
EJ Sanderlin, NR Leffler, K Lertpiriyapong, Q Cai… - … et Biophysica Acta (BBA …, 2017 - Elsevier
GPR4 is a proton-sensing G protein-coupled receptor that can be activated by extracellular
acidosis. It has recently been demonstrated that activation of GPR4 by acidosis increases …
acidosis. It has recently been demonstrated that activation of GPR4 by acidosis increases …
[HTML][HTML] Functions of the zinc-sensing receptor gpr39 in regulating intestinal health in animals
P Xia, L Yan, X Ji, Y Wu, S Lian, G Zhu - International Journal of …, 2022 - mdpi.com
G protein-coupled receptor 39 (GPR39) is a zinc-sensing receptor (ZnR) that can sense
changes in extracellular Zn2+, mediate Zn2+ signal transmission, and participate in the …
changes in extracellular Zn2+, mediate Zn2+ signal transmission, and participate in the …
[引用][C] pH sensing shapes immune cell function: The role of GPR65 and its implications for allergic disease
S de Souza Ferreira, MK Bek, CA Tibbitt - 2023 - Wiley Online Library
Immune cells show metabolic plasticity to meet their basic energetic needs as well as
provide resources for proliferation and effector function (1). Within inflamed tissues, cells …
provide resources for proliferation and effector function (1). Within inflamed tissues, cells …
[HTML][HTML] GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
Q Zhang, L Chen, H Yang, Y Fang, S Wang… - Acta Pharmacologica …, 2022 - nature.com
The putative medium-chain free fatty acid receptor GPR84 is a G protein-coupled receptor
primarily expressed in myeloid cells that constitute the innate immune system, including …
primarily expressed in myeloid cells that constitute the innate immune system, including …
Disruption of GPR35 exacerbates dextran sulfate sodium-induced colitis in mice
Background G protein-coupled receptor 35 (GPR35) is an orphan receptor and is vastly
expressed in immune cells and gastrointestinal cells, suggesting the potential physiological …
expressed in immune cells and gastrointestinal cells, suggesting the potential physiological …
IBD-associated G protein-coupled receptor 65 variant compromises signalling and impairs key functions involved in inflammation
V Mercier, G Boucher, D Devost, K Bourque… - Cellular signalling, 2022 - Elsevier
Background and aims Inflammatory bowel diseases (IBD) result in chronic inflammation of
the gastrointestinal tract. Genetic studies have shown that the GPR65 gene, as well as its …
the gastrointestinal tract. Genetic studies have shown that the GPR65 gene, as well as its …
[HTML][HTML] Differential expression of GPR15 on T cells during ulcerative colitis
A Adamczyk, D Gageik, A Frede, E Pastille, W Hansen… - JCI insight, 2017 - ncbi.nlm.nih.gov
G protein–coupled receptor 15 (GPR15) was recently highlighted as a colon-homing
receptor for murine and human CD4+ T cells. The aim of this study was to explore the …
receptor for murine and human CD4+ T cells. The aim of this study was to explore the …
[HTML][HTML] G protein-coupled receptor 109A and host microbiota modulate intestinal epithelial integrity during sepsis
G Chen, B Huang, S Fu, B Li, X Ran, D He… - Frontiers in …, 2018 - frontiersin.org
The intestinal epithelial barrier is important to mucosal immunity, although how it is
maintained after damage is unclear. Here, we show that G protein-coupled receptor 109A …
maintained after damage is unclear. Here, we show that G protein-coupled receptor 109A …
[HTML][HTML] GPR65 (TDAG8) inhibits intestinal inflammation and colitis-associated colorectal cancer development in experimental mouse models
MA Marie, EJ Sanderlin, S Satturwar, H Hong… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Abstract GPR65 (TDAG8) is a proton-sensing G protein-coupled receptor predominantly
expressed in immune cells. Genome-wide association studies (GWAS) have identified …
expressed in immune cells. Genome-wide association studies (GWAS) have identified …
pH and proton sensor GPR65 determine susceptibility to atopic dermatitis
Abstract pH sensing by GPR65 regulates various inflammatory conditions, but its role in skin
remains unknown. In this study, we performed a phenome-wide association study and report …
remains unknown. In this study, we performed a phenome-wide association study and report …