Background Patients suffering from inflammatory bowel diseases (IBDs) express increased
mucosal levels of pH-sensing receptors compared with non-IBD controls. Acidification leads …

GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory
responses. Although the precise role of GPR35 in inflammation is not yet fully understood …

The microenvironment of pancreatic ductal adenocarcinoma (PDAC) is characterized by a
dense fibrotic stroma (desmoplasia) generated by pancreatic cancer–associated fibroblasts …

Aim: To investigate the levels of G protein-coupled receptor 55 (GPR55) expression in
colonic tissue of inflammatory bowel disease (IBD) patients and healthy controls, and its …

GPR41 and GPR43 are a pair of mammalian G protein-coupled receptors (GPCRs)
expressed in human adipocytes, colon epithelial cells, and peripheral blood mononuclear …

Diet and gut microbial metabolites mediate host immune responses and are central to the
maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors …

Recent advances have shown that the abnormal inflammatory response observed in CD
involves an interplay among intestinal microbiota, host genetics and environmental factors …

The gut epithelium is a frontline barrier between luminal contents and the underlying
mucosal immune system while facilitating the transport of nutrients and water. Recent …

Background & Aims: G protein-coupled receptor 30 (GPR30) is a recently de-orphanized
estrogen receptor that mediates the effects of estrogens on different cells. It has been …

Molecular danger signals attract neutrophilic granulocytes (polymorphonuclear leukocytes
(PMNs)) to sites of infection. The G protein-coupled receptor (GPR) 43 recognizes …