Although numerous polymorphisms have been associated with inflammatory bowel disease
(IBD), identifying the function of these genetic factors has proved challenging. Here we …

Background & Aims G protein–coupled receptor (GPR) 120 has been implicated in
regulating metabolic syndromes with anti-inflammatory function. However, the role of …

GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression
has been described predominantly in immune cells. GPR84 activation is involved in the …

Intestinal epithelial cells (IECs) perform several physiological and metabolic functions at the
epithelial barrier. IECs also play an important role in defining the overall immune functions at …

Sepsis is a common critical illness in ICU and always a great difficulty in clinical treatment.
GPR43 (G protein-coupled receptor 43) participates in regulating appetite and …

Background P-glycoprotein (P-gp) plays a critical role in protection of the intestinal epithelia
by mediating efflux of drugs/xenobiotics from the intestinal mucosa into the gut lumen …

The mast cell receptor Mrgprb2, a mouse orthologue of human Mrgprx2, is known as an
inflammatory receptor and its elevated expression is associated with various diseases such …

Commensal gut microflora and dietary fiber protect against colonic inflammation and colon
cancer through unknown targets. Butyrate, a bacterial product from fermentation of dietary …

Colonic epithelial cells comprise the mucosal barrier, and their dysfunction promotes
microbial invasion from the gut lumen and induces the development of intestinal …

Objective Dysfunctional resolution of intestinal inflammation and altered mucosal healing
are essential features in the pathogenesis of inflammatory bowel disease (IBD). Intestinal …