[PDF][PDF] GPR109a: the missing link between microbiome and good health?
C Jobin - Immunity, 2014 - cell.com
A complex partnership between the host and the vast intestinal microbial ecosystem serves
numerous biological activities including nutrition, immunity, and barrier function. In this issue …
numerous biological activities including nutrition, immunity, and barrier function. In this issue …
Colitis aggravated by Mrgprb2 knockout is associated with altered immune response, intestinal barrier function and gut microbiota
M Shao, J Liu, H Luo - Experimental Physiology, 2023 - Wiley Online Library
New Findings What is the central question of this study? What is the role of mas‐related G
protein‐coupled receptor X2 (MRGPRX2/Mrgprb2) in ulcerative colitis in relation to the …
protein‐coupled receptor X2 (MRGPRX2/Mrgprb2) in ulcerative colitis in relation to the …
[HTML][HTML] Sodium butyrate inhibits inflammation and maintains epithelium barrier integrity in a TNBS-induced inflammatory bowel disease mice model
G Chen, X Ran, B Li, Y Li, D He, B Huang, S Fu, J Liu… - …, 2018 - thelancet.com
Abstract G Protein Coupled Receptor 109A (GPR109A), which belongs to the G protein
coupled receptor family, can be activated by niacin, butyrate, and β-hydroxybutyric acid …
coupled receptor family, can be activated by niacin, butyrate, and β-hydroxybutyric acid …
The function of Sphingosine-1-phosphate receptor 2 (S1PR2) in maintaining intestinal barrier and inducing ulcerative colitis
T Chen, K Gu, R Lin, Y Liu, Y Shan - Bioengineered, 2022 - Taylor & Francis
ABSTRACT Sphingosine-1-phosphate receptor 2 (S1PR2) was highly expressed in
intestinal epithelial cells (IECs) and facilitated the proliferation of IECs. However, the specific …
intestinal epithelial cells (IECs) and facilitated the proliferation of IECs. However, the specific …
[HTML][HTML] Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
Diet and the gut microbiota may underpin numerous human diseases. A major metabolic
product of commensal bacteria are short-chain fatty acids (SCFAs) that derive from …
product of commensal bacteria are short-chain fatty acids (SCFAs) that derive from …
[HTML][HTML] Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway
M Yu, R Cui, Y Huang, Y Luo, S Qin, M Zhong - EBioMedicine, 2019 - thelancet.com
Background Colorectal cancer (CRC) is one of the high incidences tumours and is ranked
second in cancer-related mortality. Even though great progress has been made, there are …
second in cancer-related mortality. Even though great progress has been made, there are …
[HTML][HTML] P2RY13 exacerbates intestinal inflammation by damaging the intestinal mucosal barrier via activating IL-6/STAT3 pathway
X Wu, S Wei, M Chen, J Li, Y Wei… - International Journal of …, 2022 - ncbi.nlm.nih.gov
The pathogenesis of ulcerative colitis (UC) is unclear, while genetic factors have been
confirmed to play an important role in its development. P2RY13 is a G protein-coupled …
confirmed to play an important role in its development. P2RY13 is a G protein-coupled …
[HTML][HTML] G protein-coupled receptor 40 activation ameliorates dextran sulfate sodium-induced colitis in mice via the upregulation of glucagon-likepeptide-2
S Kato, D Utsumi, K Matsumoto - Journal of Pharmacological Sciences, 2019 - Elsevier
G protein-coupled receptor (GPR) 40 is a receptor for long-chain free fatty acids that
enhances glucagon-like peptide (GLP)-2 production in intestinal L-cells. GLP-2 and its …
enhances glucagon-like peptide (GLP)-2 production in intestinal L-cells. GLP-2 and its …
Aminosalicylates target GPR35, partly contributing to the prevention of DSS-induced colitis
W Otkur, J Wang, T Hou, F Liu, R Yang, Y Li… - European Journal of …, 2023 - Elsevier
Abstract GPR35, a class A G-protein-coupled receptor, is considered an orphan receptor;
the endogenous ligand and precise physiological function of GPR35 remain obscure …
the endogenous ligand and precise physiological function of GPR35 remain obscure …
[HTML][HTML] Critical roles of G protein-coupled receptors in regulating intestinal homeostasis and inflammatory bowel disease
Z Feng, R Sun, Y Cong, Z Liu - Mucosal Immunology, 2022 - Elsevier
G protein-coupled receptors (GPCRs) are a group of membrane proteins that mediate most
of the physiological responses to various signaling molecules such as hormones …
of the physiological responses to various signaling molecules such as hormones …