This article provides an overview of how intestinal epithelial cells (IEC) recognize
commensals and how they maintain host-bacterial symbiosis. Endocrine, goblet cells, and …

The intestinal epithelium is a renewable tissue that requires precise balance between
proliferation and differentiation, an essential process for the formation of a tightly sealed …

Diets high in fruit and vegetables are perceived to be beneficial for intestinal homeostasis, in
health as well as in the context of inflammatory bowel diseases (IBDs). Recent …

G-protein-coupled receptors (GPRs), including pro-inflammatory ovarian cancer GPR1
(OGR1/GPR68) and anti-inflammatory T cell death-associated gene 8 (TDAG8/GPR65), are …

Introduction GPR176, an orphan G protein-coupled receptor (GPCR), is essential for the
progression of gastrointestinal cancers. However, it is still unclear how GPR176 affects …

Disturbances in intestinal immune homeostasis predispose susceptible individuals to type 1
diabetes (T1D). G-protein-coupled receptor 41 (GPR41) is a receptor for short-chain fatty …

Impaired epithelial barrier function is a hallmark of inflammatory bowel diseases, such as
colitis, contributing to diarrhoea and perpetuating inflammation. We show that the zinc …

GPR120 (encoded by FFAR4 gene) is a receptor for long chain fatty acids, activated by ω-3
Polyunsaturated Fatty Acids (PUFAs), and expressed in many cell types. Its role in the …

The mammalian gut microbiota is essential for normal intestinal development, renewal, and
repair. Injury to the intestinal mucosa can occur with infection, surgical trauma, and in …

Background Dysfunction of the immune system would disturb the intestinal homeostasis and
lead to inflammatory bowel disease (IBD). Dendritic cells (DCs) help maintain intestinal …