Commentary: Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure

RP Gajula, S Gaddameedhi - Frontiers in Physiology, 2015 - frontiersin.org
Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in the
western world (Bowden, 2004). Frequency of its occurrence is closely associated with skin …

Blue light impairs the repair of UVB‐induced pyrimidine dimers in a human skin model

T Douki, D Bacqueville, C Jacques… - Photochemistry and …, 2024 - Wiley Online Library
In recent years, interest is growing in the biological cutaneous effects of high‐energy visible
light (400–450 nm). In the present study, we explored the impact of blue light (BL) on the …

Melanin photosensitizes ultraviolet light (UVC) DNA damage in pigmented cells

CA Huselton, HZ Hill, JP O'Neill - Environmental and molecular …, 1990 - Wiley Online Library
Melanins, pigments of photoprotection and camouflage, are very photoreactive and can both
absorb and emit active oxygen species. Nevertheless, black skinned individuals rarely …

Melanin: a two edged sword?

HZ Hill, W Li, P Xin, DL Mitchell - Pigment cell research, 1997 - Wiley Online Library
Melanin is both photosensitizer and photoprotector. Skin cancer rates decrease with
increasing constitutive pigmentation, yet the pigment has been shown to be photoreactive …

Cell‐intrinsic melanin fails to protect melanocytes from ultraviolet‐mutagenesis in the absence of epidermal melanin

TJ Weiss, ER Crawford, V Posada… - Pigment cell & …, 2023 - Wiley Online Library
Melanin is a free‐radical scavenger, antioxidant, and broadband absorber of ultraviolet (UV)
radiation which protects the skin from environmental carcinogenesis. However, melanin …

[HTML][HTML] The role of melanin in the induction of oxidative DNA base damage by ultraviolet A irradiation of DNA or melanoma cells

E Kvam, RM Tyrrell - Journal of Investigative Dermatology, 1999 - Elsevier
Highly pigmented, dark skin is more resistant to the harmful effects of solar ultraviolet
radiation than light-colored human skin. The extent to which tanning protects skin from …

DNA photodamage stimulates melanogenesis and other photoprotective responses

BA Gilchrest, MS Eller - Journal of Investigative Dermatology Symposium …, 1999 - Elsevier
Ultraviolet (UV) irradiation is a major source of environmental damage to skin. Melanin
pigmentation protects against this damage by absorbing UV photons and UV-generated free …

[HTML][HTML] (Pheo) melanin photosensitizes UVA-induced DNA damage in cultured human melanocytes

E Wenczl, NPM Smit, S Pavel, AA Schothorst… - Journal of investigative …, 1998 - Elsevier
The question of whether melanins are photoprotecting and/or photosensitizing in human
skin cells continues to be debated. To evaluate the role of melanin upon UVA irradiation …

[PDF][PDF] Dark CPD s and photocarcinogenesis: the party continues after the lights go out

ZA Abdel‐Malek, P Cassidy - 2015 - academia.edu
Exposure to solar UV radiation is the main cause for all forms of skin cancers, including
melanoma. UVB photons (290–320 nm wavelength) represent the most energetic and …

[HTML][HTML] Novel properties of melanins include promotion of DNA strand breaks, impairment of repair, and reduced ability to damage DNA after quenching of singlet …

AA Suzukawa, A Vieira, SMB Winnischofer… - Free Radical Biology …, 2012 - Elsevier
Melanins have been associated with the development of melanoma and its resistance to
photodynamic therapy (PDT). Singlet molecular oxygen (1O2), which is produced by …