The main effects of aldosterone, the most physiologically important mineralocorticoid, are on
electrolyte transport across epithelia, particularly in the kidney, but also in other tissues, such …

Classically, aldosterone is a steroid hormone secreted from the adrenal cortex, which acts
on kidney, colon and sweat/salivary glands to promote unidirectional sodium transport …

Until relatively recently, the mineralocorticoid hormone aldosterone was thought to be
produced uniquely in the adrenal cortex and to act exclusively on epithelia to promote …

The hormone aldosterone has a well-recognized physiological role in epithelial fluid and
electrolyte homeostasis, and more recently defined pathophysiological roles in the …

Recent views suggest that long-term exposure to elevated aldosterone concentrations might
result in cardiac, vascular, renal, and metabolic sequelae that occur independent of the …

Aldosterone and cardiovascular disease : Current Opinion in Endocrinology, Diabetes and
Obesity Aldosterone and cardiovascular disease : Current Opinion in Endocrinology, Diabetes …

Circulating aldosterone is principally made in the glomerulosa zone of the adrenal cortex by
a series of enzyme steps leading to the conversion of cholesterol to aldosterone. Uniquely …

The advent of antihypertensive therapy has resulted in a significant decrease in
cardiovascular morbidity and mortality. Nevertheless, the incidence of heart failure, stroke …

ALTHOUGH the clinical importance of the adrenal cortex in the regulation of electrolyte
balance had long been realized (1), it was not until the early 1950s that the major regulatory …

Blockade of the renin-angiotensin-aldosterone system with angiotensin-converting enzyme
(ACE) inhibitors or angiotensin receptor antagonists has resulted in beneficial effects in …