A comprehensive guide to drug transporters that influence the absorption, distribution, and
elimination of drugs in the body The development of powerful expression cloning and …

It is now becoming increasingly clear that metabolism alone cannot adequately account for
the observed intersubject variability in drug disposition or response. Carrier-mediated …

It is increasingly recognized that various transporter proteins are expressed throughout the
body and determine absorption, tissue distribution, biliary and renal elimination of …

Since 1994, researchers have isolated various genes encoding transporter proteins
involved in drug uptake into and eŒux from tissues that play key roles in the absorption …

Drug transporters play important roles in the absorption, distribution, metabolism and
excretion of drugs, pesticides, signaling molecules, heavy metal conjugates, components of …

Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and
brain, and play key roles in drug absorption, distribution, and excretion. The information on …

The efficacy of drug therapy results from the complex interplay of multiple processes that
govern drug disposition and response. Most studies to date have focused on the contribution …

Membrane transporters are integral membrane proteins typically having 12 transmembrane
domains. Most of the SLC family transporters consist of 300–800 amino acid residues with a …

Transporters comprise the largest family of membrane proteins in human organism,
including members of solute carrier transporter and ATP-binding cassette transporter …

Drug transporters expressed in various tissues play a signiˆcant role in drug disposition. By
regulating the function of such transporters, it may be possible to eventually develop drugs …