Due to differences in human and murine angiotensin converting enzyme 2 (ACE-2) receptor,
initially available SARS-CoV-2 isolates could not infect mice. Here we show that serial …

SARS-CoV-2 is of zoonotic origin and contains a PRRA polybasic cleavage motif which is
considered critical for efficient infection and transmission in humans. We previously reported …

ABSTRACT The Coronavirus Disease 2019 (COVID-19) pandemic continues to cause
extraordinary loss of life and economic damage. Animal models of severe acute respiratory …

Unrelated individuals can produce genetically similar clones of antibodies, known as public
clonotypes, which have been seen in responses to different infectious diseases, as well as …

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) possesses a
discriminative polybasic cleavage motif in its spike protein that is recognized by the host …

Neutralizing antibodies against the SARS-CoV-2 spike (S) protein are a goal of COVID-19
vaccines and have received emergency use authorization as therapeutics. However, viral …

Introduction The spectrum of SARS-CoV-2 mutations have increased over time, resulting in
the emergence of several variants of concern. Persistent infection is assumed to be involved …

Recently identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
Mu and C. 1.2 have spike proteins with mutations that may confer resistance to natural and …

Background Wildtype mice are not susceptible to SARS-CoV-2 infection. Emerging SARS-
CoV-2 variants, including B. 1.1. 7, B. 1.351, P. 1, and P. 3, contain mutations in spike that …

In the latest issues of Cell Host & Microbe and Cell, three articles describe new mutations in
the SARS-CoV-2 Spike receptor binding domain that escape neutralizing responses. These …