Information-theory-based benchmarking and feature selection algorithm improve cell type annotation and reproducibility of single cell RNA-seq data analysis …

Z Ren, M Gerlach, H Shi, AV Misharin, GRS Budinger… - bioRxiv, 2020 - biorxiv.org
Single cell RNA sequencing (scRNA-seq), which promises to enable the quantitative study
of biological processes at the single cell level, are now a routine part of experimental …

scCATCH: automatic annotation on cell types of clusters from single-cell RNA sequencing data

X Shao, J Liao, X Lu, R Xue, N Ai, X Fan - Iscience, 2020 - cell.com
Recent advancements in single-cell RNA sequencing (scRNA-seq) have facilitated the
classification of thousands of cells through transcriptome profiling, wherein accurate cell …

scPLAN: a hierarchical computational framework for single transcriptomics data annotation, integration and cell-type label refinement

Q Guo, M Yuan, L Zhang, M Deng - Briefings in Bioinformatics, 2024 - academic.oup.com
Motivation In the past decade, single-cell RNA sequencing (scRNA-seq) has emerged as a
pivotal method for transcriptomic profiling in biomedical research. Precise cell-type …

Imbalance and Composition Correction Ensemble Learning Framework (ICCELF): A novel framework for automated scRNA-seq cell type annotation

S Cui, S Nassiri, I Zakeri - bioRxiv, 2024 - biorxiv.org
Single-cell RNA sequencing (scRNA-seq) has gained broad utility and success in revealing
novel biological insight in preclinical and clinical investigations. Cell type annotation …

One Cell At a Time: A Unified Framework to Integrate and Analyze Single-cell RNA-seq Data

CX Wang, L Zhang, B Wang - bioRxiv, 2021 - biorxiv.org
The surge of single-cell RNA sequencing technologies gives rise to the abundance of large
single-cell RNA-seq datasets at the scale of hundreds of thousands of single cells …

Addressing the looming identity crisis in single cell RNA-seq

M Crow, A Paul, S Ballouz, ZJ Huang, J Gillis - bioRxiv, 2017 - biorxiv.org
Single cell RNA-sequencing technology (scRNA-seq) provides a new avenue to discover
and characterize cell types, but the experiment-specific technical biases and analytic …

Improving replicability in single-cell RNA-Seq cell type discovery with Dune

H Roux de Bézieux, K Street, S Fischer… - BMC …, 2024 - Springer
Background Single-cell transcriptome sequencing (scRNA-Seq) has allowed new types of
investigations at unprecedented levels of resolution. Among the primary goals of scRNA …

CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments

HA Ekiz, CJ Conley, WZ Stephens, RM O'Connell - BMC bioinformatics, 2020 - Springer
Background Single cell RNA sequencing (scRNAseq) has provided invaluable insights into
cellular heterogeneity and functional states in health and disease. During the analysis of …

CIA: a Cluster Independent Annotation method to investigate cell identities in scRNA-seq data

I Ferrari, M Battistella, F Vincenti, A Gobbini, F Marini… - bioRxiv, 2023 - biorxiv.org
Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of the
transcriptional landscape of complex tissues, enabling the discovery of novel cell types and …

scID: identification of transcriptionally equivalent cell populations across single cell RNA-seq data using discriminant analysis

K Boufea, S Seth, NN Batada - BioRxiv, 2018 - biorxiv.org
The power of single cell RNA sequencing (scRNA-seq) stems from its ability to uncover cell
type-dependent phenotypes, which rests on the accuracy of cell type identification. However …