Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disorder caused by dysfunction and
degeneration of motor neurons. Multiple disease-causing mutations, including in the genes …

Amyotrophic lateral sclerosis (ALS) is a devastating paralytic disorder caused by dysfunction
and degeneration of motoneurons starting in adulthood. Recent studies using cell or animal …

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that primarily
affects motoneurons in the brain and spinal cord. Dominant mutations in superoxide …

Mutations in superoxide dismutase-1 (SOD1) cause a form of the fatal paralytic disorder
amyotrophic lateral sclerosis (ALS), presumably by a combination of cell-autonomous and …

Motoneuron loss and reactive astrocytosis are pathological hallmarks of amyotrophic lateral
sclerosis (ALS), a paralytic neurodegenerative disease that can be triggered by mutations in …

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease that leads to loss of motor
function and early death. About 5% of cases are inherited, with the majority of identified …

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with no cure.
Breakthroughs in understanding ALS pathogenesis came with the discovery of dominant …

The selective degeneration of motoneuron that typifies amyotrophic lateral sclerosis (ALS)
implicates non‐cell‐autonomous effects of astrocytes. However, mechanisms underlying …

Death pathways restricted to specific neuronal classes could potentially allow for precise
control of developmental neuronal death and also underlie the selectivity of neuronal loss in …

The reasons for the cellular specificity and slow progression of motoneuron diseases such
as ALS are still poorly understood. We previously described a motoneuron-specific cell …