Abstract Degenerative Cervical Myelopathy (DCM) is the functional derangement of the
spinal cord and acts as one of the most common atraumatic spinal cord injuries. Magnetic …

Translation of diffusion MRI-derived quantitative biomarkers into clinical decision making
has been hampered by within-scanner and cross-scanner variability. We compare intra …

Quantitative imaging biomarkers (QIBs) can be defined as objective measures that are
sensitive and specific to changes in tissue physiology. Provided the acquired QIBs are not …

In clinical diagnostics and longitudinal studies, the reproducibility of MRI assessments is of
high importance in order to detect pathological changes, but developments in MRI hard-and …

Purpose: Estimation of uncertainty of MAP-MRI metrics is an important topic, for several
reasons. Bootstrap derived uncertainty, such as the standard deviation, provides valuable …

Diffusion tensor imaging (DTI) is the most widely used method for characterizing
noninvasively structural and architectural features of brain tissues. However, the assumption …

Background Diffusion tensor imaging (DTI) parameters, such as fractional anisotropy (FA),
allow examining the structural integrity of the brain. However, the true value of these …

When analyzing multi-site diffusion MRI (dMRI) data, metrics should be harmonized to
remove the site effect. In this study, we applied the combined association test (ComBat) …

MRI-based multi-site trials now routinely include some form of diffusion-weighted imaging
(DWI) in their protocol. These studies can include data originating from scanners built by …

Normative models of brain metrics based on large populations are extremely valuable for
detecting brain abnormalities in patients with dementia, psychiatric, or developmental …