Clinical Characteristics at Initial Presentation and Impact of Dual Therapy on the Outcome of Bacteremic Streptococcus pneumoniae Pneumonia in Adults

K Weiss, DE Low, L Cortes, A Beaupre… - Canadian respiratory …, 2004 - Wiley Online Library
BACKGROUND: Approximately 10% of patients hospitalized with community‐acquired
pneumonia (CAP) are bacteremic. Bacteremic Streptococcus pneumoniae pneumonia …

Monotherapy versus combination antibiotic therapy for patients with bacteremic Streptococcus pneumoniae community-acquired pneumonia

R Chokshi, MI Restrepo, N Weeratunge… - European Journal of …, 2007 - Springer
The purpose of this study was to examine the impact of antimicrobial monotherapy vs
combination therapy on length of stay and mortality for patients with Streptococcus …

Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia

LM Baddour, VL Yu, KP Klugman… - American journal of …, 2004 - atsjournals.org
Retrospective studies have suggested that combination antibiotic therapy for severe
bacteremic pneumococcal pneumonia may reduce mortality. We assessed this issue in a …

What is optimal antimicrobial therapy for bacteremic pneumococcal pneumonia?

TM File Jr, LA Mandell - Clinical infectious diseases, 2003 - academic.oup.com
Streptococcus pneumoniae is the leading cause of community-acquired pneumonia (CAP)
and accounts for approximately two-thirds of cases of CAP associated with mortality [1]. The …

The controversy of combination vs monotherapy in the treatment of hospitalized community-acquired pneumonia

K Weiss, GS Tillotson - Chest, 2005 - Elsevier
Background The majority of community-acquired pneumonia (CAP) patients (about 80%)
will be treated as outpatients, because therapy with a single agent will work. For the …

Monotherapy may be suboptimal for severe bacteremic pneumococcal pneumonia

GW Waterer, GW Somes… - Archives of internal …, 2001 - jamanetwork.com
Background Although monotherapy for pneumococcal pneumonia is standard, a survival
benefit of combination β-lactam and macrolide therapy has been suggested. Hypothesis …

Addition of a macrolide to a β-lactam-based empirical antibiotic regimen is associated with lower in-hospital mortality for patients with bacteremic pneumococcal …

JA Martínez, JP Horcajada, M Almela… - Clinical Infectious …, 2003 - academic.oup.com
To assess the association between inclusion of a macrolide in a β-lactam—based empirical
antibiotic regimen and mortality among patients with bacteremic pneumococcal pneumonia …

Effectiveness of combination therapy versus monotherapy with a third-generation cephalosporin in bacteraemic pneumococcal pneumonia: a propensity score …

C De la Calle, HG Ternavasio-de la Vega, L Morata… - Journal of Infection, 2018 - Elsevier
Objective Combining a macrolide or a fluoroquinolone to beta-lactam regimens in the
treatment of patients with moderate to severe community-acquired pneumonia is …

Revisiting Combination Antibiotic Therapy for Community-Acquired Invasive Streptococcus pneumoniae Pneumonia

MA Mufson, RJ Stanek - Clinical infectious diseases, 2006 - academic.oup.com
Sir—In a previously published article [1], we showed that adults 50 years of age with
invasive Streptococcus pneumoniae pneumonia given combination antibiotic therapy …

[HTML][HTML] Combination antibiotic therapy for community-acquired pneumonia

J Caballero, J Rello - Annals of intensive care, 2011 - Springer
Community-acquired pneumonia (CAP) is a common and potentially serious illness that is
associated with morbidity and mortality. Although medical care has improved during the past …