KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain
The lysine acetyltransferases type 3 (KAT3) family members CBP and p300 are important
transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain …
transcriptional co-activators, but their specific functions in adult post-mitotic neurons remain …
CBP/p300 in brain development and plasticity: disentangling the KAT's cradle
Highlights•CBP and p300 (KAT3s) interact with dozens of TFs and acetylate hundreds of
substrates.•KAT3s have both unique and overlapping functions during neural …
substrates.•KAT3s have both unique and overlapping functions during neural …
KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain
MI Bergamasco, W Abeysekera… - Life Science …, 2025 - life-science-alliance.org
Heterozygous mutations in the histone lysine acetyltransferase gene KAT6B
(MYST4/MORF/QKF) underlie neurodevelopmental disorders, but the mechanistic roles of …
(MYST4/MORF/QKF) underlie neurodevelopmental disorders, but the mechanistic roles of …
TIP60/KAT5 is required for neuronal viability in hippocampal CA1
Aberrant histone acetylation contributes to age-dependent cognitive decline and
neurodegenerative diseases. We analyze the function of lysine acetyltransferase …
neurodegenerative diseases. We analyze the function of lysine acetyltransferase …
[HTML][HTML] Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7
In the conventional model of transcriptional activation, transcription factors bind to response
elements and recruit co-factors, including histone acetyltransferases. Contrary to this model …
elements and recruit co-factors, including histone acetyltransferases. Contrary to this model …
The aPKC-CBP pathway regulates adult hippocampal neurogenesis in an age-dependent manner
While epigenetic modifications have emerged as attractive substrates to integrate
environmental changes into the determination of cell identity and function, specific signals …
environmental changes into the determination of cell identity and function, specific signals …
A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice
S Chatterjee, P Mizar, R Cassel, R Neidl… - Journal of …, 2013 - Soc Neuroscience
Although the brain functions of specific acetyltransferases such as the CREB-binding protein
(CBP) and p300 have been well documented using mutant transgenic mice models, studies …
(CBP) and p300 have been well documented using mutant transgenic mice models, studies …
K‐Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation
RM Stilling, R Rönicke, E Benito, H Urbanke… - The EMBO …, 2014 - embopress.org
Neuronal histone acetylation has been linked to memory consolidation, and targeting
histone acetylation has emerged as a promising therapeutic strategy for neuropsychiatric …
histone acetylation has emerged as a promising therapeutic strategy for neuropsychiatric …
Lysine acetyltransferase 8 is involved in cerebral development and syndromic intellectual disability
L Li, M Ghorbani, M Weisz-Hubshman… - The Journal of …, 2020 - Am Soc Clin Investig
Epigenetic integrity is critical for many eukaryotic cellular processes. An important question
is how different epigenetic regulators control development and influence disease. Lysine …
is how different epigenetic regulators control development and influence disease. Lysine …
Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis
Acetylation of lysine 16 on histone H4 (H4K16ac) is catalyzed by histone acetyltransferase
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …
KAT8 and can prevent chromatin compaction in vitro. Although extensively studied in …