[HTML][HTML] Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

JW Golden, CR Cline, X Zeng, AR Garrison, BD Carey… - JCI insight, 2020 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 has created an international health crisis, and small animal
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …

Genome-wide analysis of SARS-CoV-2 virus strains circulating worldwide implicates heterogeneity

MR Islam, MN Hoque, MS Rahman, ASMRU Alam… - Scientific reports, 2020 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel evolutionary
divergent RNA virus, is responsible for the present devastating COVID-19 pandemic. To …

COVID-19 outcomes and the human genome

MF Murray, EE Kenny, MD Ritchie, DJ Rader… - Genetics in …, 2020 - nature.com
BACKGROUND In the COVID-19 pandemic, the opportunity to link host genomic factors to
the highly variable clinical manifestations of SARS-CoV-2 infection has been widely …

The evolution and biology of SARS-CoV-2 variants

A Telenti, EB Hodcroft… - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Our understanding of the still unfolding severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) pandemic would have been extremely limited without the study of the …

ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities

N Zamorano Cuervo, N Grandvaux - elife, 2020 - elifesciences.org
Pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
coronavirus 19 disease (COVID-19) which presents a large spectrum of manifestations with …

Single‐cell RNA analysis on ACE2 expression provides insights into SARS‐CoV‐2 potential entry into the bloodstream and heart injury

J Guo, X Wei, Q Li, L Li, Z Yang, Y Shi… - Journal of Cellular …, 2020 - Wiley Online Library
Abstract Coronavirus disease‐2019 (COVID‐19) is a global pandemic with high infectivity
and pathogenicity, accounting for tens of thousands of deaths worldwide. Recent studies …

COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease

R Sheervalilou, M Shirvaliloo… - Journal of Cellular …, 2020 - Wiley Online Library
Months after the outbreak of a new flu‐like disease in China, the entire world is now in a
state of caution. The subsequent less‐anticipated propagation of the novel coronavirus …

COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

S Beyerstedt, EB Casaro, ÉB Rangel - European journal of clinical …, 2021 - Springer
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-
converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell …

A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor

M Oz, DE Lorke, N Kabbani - Pharmacology & therapeutics, 2021 - Elsevier
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

The human coronaviruses (HCoVs) and the molecular mechanisms of SARS-CoV-2 infection

L Santacroce, IA Charitos, DM Carretta… - Journal of Molecular …, 2021 - Springer
In humans, coronaviruses can cause infections of the respiratory system, with damage of
varying severity depending on the virus examined: ranging from mild-to-moderate upper …