Intramolecular ipso-Halocyclization of 4-(p-Unsubstituted-aryl)-1-alkynes Leading to Spiro[4,5]trienones: Scope, Application, and Mechanistic Investigations

BX Tang, YH Zhang, RJ Song, DJ Tang… - The Journal of …, 2012 - ACS Publications
A new, general method for the synthesis of spiro [4, 5] trienones is described by the
intramolecular ipso-halocyclization of 4-(p-unsubstituted-aryl)-1-alkynes. In the presence of …

Alkylation/Ipso-cyclization of Active Alkynes Leading to 3-Alkylated Aza-and Oxa-spiro [4, 5]-trienones

P Chen, JH Fan, WQ Yu, BQ Xiong, Y Liu… - The Journal of …, 2022 - ACS Publications
A method for the preparation of 3-alkylated spiro [4.5] trienones via alkylation/ipso-
cyclization of activated alkynes with 4-alkyl-DHPs under transition-metal-free conditions is …

Selective Synthesis of Spiro[4,5]trienyl Acetates via an Intramolecular Electrophilic ipso-Iodocyclization Process

BX Tang, DJ Tang, S Tang, QF Yu, YH Zhang… - Organic …, 2008 - ACS Publications
A general and efficient intramolecular electrophilic ipso-iodocyclization of para-unactivated
arylalkynes has been developed for the synthesis of spiro [4, 5] trienyl acetates. In the …

Facile synthesis of halogenated spiroketals via a tandem iodocyclization

J Wang, HT Zhu, YX Li, LJ Wang, YF Qiu, ZH Qiu… - Organic …, 2014 - ACS Publications
A strategy for the synthesis of spiroketal compounds through a tandem iodocyclization of 1-
(2-ethynylphenyl)-4-hydroxybut-2-yn-1-one derivatives is presented. This reaction could …

Synthesis of Spiro[4.5]trienones by Intramolecular ipso-Halocyclization of 4-(p-Methoxyaryl)-1-alkynes

X Zhang, RC Larock - Journal of the American Chemical Society, 2005 - ACS Publications
A wide variety of 3-halospiro [4.5] trienones are readily prepared in good to excellent yields
by the intramolecular ipso-halocyclization of 4-(p-methoxyaryl)-1-alkynes under mild …

General approach to a spiro indole-3, 1′-naphthalene tetracyclic system: stereoselective pseudo four-component reaction of isatins and cyclic ketones with two …

MN Elinson, AN Vereshchagin, RF Nasybullin… - RSC Advances, 2015 - pubs.rsc.org
A new type of catalytic stereoselective cascade pseudo four-component reaction was
discovered. The simple and facile pseudo four-component reaction of isatins, cyclic ketones …

Domino cyclization–alkylation protocol for the synthesis of 2, 3-functionalized indoles from o-alkynylanilines and allylic alcohols

C Xu, VK Murugan, SA Pullarkat - Organic & Biomolecular Chemistry, 2012 - pubs.rsc.org
Domino cyclization– alkylation protocol for the synthesis of 2,3-functionalized indoles from o
-alkynylanilines and allylic alcohols - Organic & Biomolecular Chemistry (RSC Publishing) …

Organic-base-catalyzed synthesis of phthalides via highly regioselective intramolecular cyclization reaction

C Kanazawa, M Terada - Tetrahedron letters, 2007 - Elsevier
The organic-base-catalyzed 5-exo intramolecular cyclization reaction of o-alkynylbenzoic
acid produces the corresponding phthalide regioselectively in good to excellent yields. The …

Efficient synthesis of tetrahydronaphthalene-or isochroman-fused spirooxindoles using tandem reactions

B Wang, HJ Leng, XY Yang, B Han, CL Rao, L Liu… - RSC …, 2015 - pubs.rsc.org
The flexible and simple cascade reaction involving a Michael–aldol or vinylogous Henry-
acetalization relay is described. We have used the cascade reaction to assemble …

Electrophilic Cyclization of 2-(1-Alkynyl)-2-alken-1-ones Using the I2/K3PO4 System:  An Efficient Synthesis of Highly Substituted Iodofurans

Y Liu, S Zhou - Organic Letters, 2005 - ACS Publications
The electrophilic cyclization of 2-(1-alkynyl)-2-alken-1-ones in the presence of various
alcohols or carbon-based nucleophiles offers an efficient and straightforward route to highly …