Pro-inflammatory cytokines cause b-cell dysfunction and death. The aim of this study was to
investigate the interactions between different pro-and anti-inflammatory cytokines and their …

We have investigated the effects of prolonged exposure (24 h) to pro-inflammatory cytokines
on β-cell metabolism and insulin secretion using clonal BRIN-BD11 β cells. Addition of IL …

Proinflammatory cytokines produced by immune cells destroy pancreatic beta cells in type 1
diabetes. The aim of this study was to investigate the cytokine network and its effects in …

Insulin-dependent diabetes mellitus is an autoimmune disease characterized by the
selective destruction of the pancreatic β-cell. The autoimmune response that is ultimately …

Insulin-dependent diabetes mellitus (IDDM) is a disease that results from autoimmune
destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. The …

Cytokines, such as IL-1β and TNF-α, contribute to pancreatic β-cell death in type 1 diabetes
mellitus. The transcription factor nuclear factor-κB (NF-κB) mediates cytokine-induced β-cell …

Pancreatic b-cell homeostasis is a balance between programmed cell death (apoptosis) and
regeneration. Although autoimmune diabetes mellitus type 1 (DM1) is the most-studied …

Cytokines produced by immune system cells infiltrating pancreatic islets are candidate
mediators of islet beta-cell destruction in autoimmune insulin-dependent diabetes mellitus …

Recent observations suggest a role for interleukin 1 (IL-1), a macrophage-derived cytokine,
in the autoimmune B cell destruction, which is observed in type 1 diabetes. In the present …

It is broadly accepted that the main cause of type 2 dia-betes is overfeeding. Unclear is how
this metabolic stress is translated into signals leading to defective insulin secretion and …