Engineering Cardiac Tissue for Advanced Heart‐On‐A‐Chip Platforms
X Chen, S Liu, M Han, M Long, T Li… - Advanced …, 2024 - Wiley Online Library
Cardiovascular disease is a major cause of mortality worldwide, and current preclinical
models including traditional animal models and 2D cell culture models have limitations in …
models including traditional animal models and 2D cell culture models have limitations in …
Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial …
Cardiovascular disease morbidity has increased worldwide. Organs‐on‐chips and human
pluripotent stem cell (hPSC) technologies aid to overcome some of the limitations in cardiac …
pluripotent stem cell (hPSC) technologies aid to overcome some of the limitations in cardiac …
Recent progress of organ-on-a-chip towards cardiovascular diseases: advanced design, fabrication, and applications
Cardiovascular diseases (CVDs) are a major cause of death worldwide, leading to
increased medical care costs. To turn the scale, it is essential to acquire a more in-depth and …
increased medical care costs. To turn the scale, it is essential to acquire a more in-depth and …
Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues
A Marsano, C Conficconi, M Lemme, P Occhetta… - Lab on a Chip, 2016 - pubs.rsc.org
In the past few years, microfluidic-based technology has developed microscale models
recapitulating key physical and biological cues typical of the native myocardium. However …
recapitulating key physical and biological cues typical of the native myocardium. However …
Generation of functional cardiac microtissues in a beating heart-on-a-chip
With the increasing attention on cardiovascular disorders and the current inability of pre-
clinical models to accurately predict human physiology, the need for advanced and reliable …
clinical models to accurately predict human physiology, the need for advanced and reliable …
From cardiac tissue engineering to heart-on-a-chip: beating challenges
The heart is one of the most vital organs in the human body, which actively pumps the blood
through the vascular network to supply nutrients to as well as to extract wastes from all other …
through the vascular network to supply nutrients to as well as to extract wastes from all other …
Step-by-step fabrication of heart-on-chip systems as models for cardiac disease modeling and drug screening
Cardiovascular diseases are caused by hereditary factors, environmental conditions, and
medication-related issues. On the other hand, the cardiotoxicity of drugs should be …
medication-related issues. On the other hand, the cardiotoxicity of drugs should be …
Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip
J Veldhuizen, J Cutts, DA Brafman, RQ Migrino… - Biomaterials, 2020 - Elsevier
Despite significant efforts in the study of cardiovascular diseases (CVDs), they persist as the
leading cause of mortality worldwide. Considerable research into human pluripotent stem …
leading cause of mortality worldwide. Considerable research into human pluripotent stem …
Designing biomaterial platforms for cardiac tissue and disease modeling
Heart disease is one of the leading causes of death in the world. There is a growing demand
for in vitro cardiac models that can recapitulate the complex physiology of the cardiac tissue …
for in vitro cardiac models that can recapitulate the complex physiology of the cardiac tissue …
Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform
Organ-on-a-chip systems have the potential to revolutionize drug screening and disease
modeling through the use of human stem cell-derived cardiomyocytes. The predictive power …
modeling through the use of human stem cell-derived cardiomyocytes. The predictive power …