A recombinant VSV-vectored vaccine rapidly protects nonhuman primates against heterologous lethal Lassa fever

RW Cross, C Woolsey, AN Prasad, V Borisevich… - Cell reports, 2022 - cell.com
Lassa virus (LASV) is recognized by the World Health Organization as one of the top five
pathogens likely to cause a severe outbreak. A recent unprecedented resurgence of LASV …

A recombinant vesicular stomatitis virus-based Lassa fever vaccine protects guinea pigs and macaques against challenge with geographically and genetically distinct …

D Safronetz, C Mire, K Rosenke… - PLoS neglected …, 2015 - journals.plos.org
Background Lassa virus (LASV) is endemic in several West African countries and is the
etiological agent of Lassa fever. Despite the high annual incidence and significant morbidity …

Advanced vaccine candidates for Lassa fever

IS Lukashevich - Viruses, 2012 - mdpi.com
Lassa virus (LASV) is the most prominent human pathogen of the Arenaviridae. The virus is
transmitted to humans by a rodent reservoir, Mastomys natalensis, and is capable of causing …

[HTML][HTML] Vaccine platforms for the prevention of Lassa fever

J Purushotham, T Lambe, SC Gilbert - Immunology Letters, 2019 - Elsevier
Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus (LASV), which is
endemic throughout much of West Africa. The virus primarily circulates in the Mastomys …

Current research for a vaccine against Lassa hemorrhagic fever virus

BM Warner, D Safronetz, DR Stein - Drug design, development and …, 2018 - Taylor & Francis
Lassa virus (LASV) is a rodent-borne arenavirus endemic to several West African countries
that causes Lassa fever (LF). LF is typically mild but it can cause severe disease …

[HTML][HTML] Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques

J Jiang, P Banglore, KA Cashman… - Human Vaccines & …, 2019 - Taylor & Francis
Lassa virus (LASV) is a hemorrhagic fever virus of the Arenaviridae family with high rates of
mortality and co-morbidities, including chronic seizures and permanent bilateral or unilateral …

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains

M Mateo, S Reynard, A Journeaux, C Germain… - Science Translational …, 2021 - science.org
A safe and protective Lassa virus vaccine is crucially needed in Western Africa to stem the
recurrent outbreaks of Lassa virus infections in Nigeria and the emergence of Lassa virus in …

Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shot

M Mateo, S Reynard, X Carnec, A Journeaux… - Science translational …, 2019 - science.org
Lassa fever is a major threat in Western Africa. The large number of people living at risk for
this disease calls for the development of a vaccine against Lassa virus (LASV). We …

Lassa fever—the road ahead

RF Garry - Nature Reviews Microbiology, 2023 - nature.com
Lassa virus (LASV) is endemic in the rodent populations of Sierra Leone, Nigeria and other
countries in West Africa. Spillover to humans occurs frequently and results in Lassa fever, a …

A Lassa fever live-attenuated vaccine based on codon deoptimization of the viral glycoprotein gene

Y Cai, C Ye, B Cheng, A Nogales, M Iwasaki, S Yu… - Mbio, 2020 - Am Soc Microbiol
Lassa virus (LASV) is endemic in Western Africa and is estimated to infect hundreds of
thousands of individuals annually. A considerable number of these infections result in Lassa …