Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …

Circadian clocks constitute the evolutionary molecular machinery that dictates the temporal
regulation of physiology to maintain homeostasis. Disruption of the circadian rhythm plays a …

Disruption of the cellular pathway modulating endogenous 24-h rhythms, referred to as “the
circadian clock”, has been recently proven to be associated with cancer risk, development …

Circadian clocks participate in the coordination of various metabolic and biological activities
to maintain homeostasis. Disturbances in the circadian rhythm and cancers are closely …

Circadian clocks are ubiquitous timing mechanisms that generate approximately 24-h
rhythms in cellular and bodily functions across nearly all living species. These internal clock …

The circadian timing system drives daily rhythmic changes in drug metabolism and controls
rhythmic events in cell cycle, DNA repair, apoptosis, and angiogenesis in both normal tissue …

BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …

Cancer chronotherapy aims at enhancing tolerability and efficacy of anticancer drugs
through their delivery according to circadian clocks. However, mouse and patient data show …

The circadian clock is an endogenous timekeeper system that controls the daily rhythms of a
variety of physiological processes. Accumulating evidence indicates that genetic changes or …

Circadian rhythms regulate a remarkable variety of physiologic functions in living organisms.
Circadian disruption is associated with tumorigenesis and tumor progression through effects …