Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates

B Malengier-Devlies, J Filtjens, K Ahmadzadeh… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural
killer (NK) cells play an important role in innate immune responses to viral infections. Here …

Early expansion of activated adaptive but also exhausted NK cells during acute severe SARS-CoV-2 infection

M Claus, N Pieris, D Urlaub, P Bröde… - Frontiers in Cellular …, 2023 - frontiersin.org
The analysis of immunological parameters during the course of a SARS-CoV-2 infection is of
great importance, both to identify diagnostic markers for the risk of a severe course of COVID …

NK and T cell immunological signatures in hospitalized patients with COVID-19

L Bergantini, M d'Alessandro, P Cameli, D Cavallaro… - Cells, 2021 - mdpi.com
Severe acute respiratory syndrome caused by coronavirus 2 emerged in Wuhan (China) in
December 2019 and has severely challenged the human population. NK and T cells are …

Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19

M Osman, RM Faridi, W Sligl, MT Shabani-Rad… - Blood …, 2020 - ashpublications.org
The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–
driven coronavirus disease 2019 (COVID-19) has caused unprecedented human death and …

Abnormality in the NK-cell population is prolonged in severe COVID-19 patients

G Leem, S Cheon, H Lee, SJ Choi, S Jeong… - Journal of Allergy and …, 2021 - Elsevier
Background Our understanding of adaptive immune responses in patients with coronavirus
disease 2019 (COVID-19) is rapidly evolving, but information on the innate immune …

[HTML][HTML] Natural killer cells in SARS-CoV-2 infection: pathophysiology and therapeutic implications

C Di Vito, F Calcaterra, N Coianiz, S Terzoli… - Frontiers in …, 2022 - frontiersin.org
Natural Killer (NK) cells are lymphocytes of the innate immunity that play a crucial role in the
control of viral infections in the absence of a prior antigen sensitization. Indeed, they display …

Natural killer cell immunotypes related to COVID-19 disease severity

C Maucourant, I Filipovic, A Ponzetta, S Aleman… - Science …, 2020 - science.org
Understanding innate immune responses in coronavirus disease 2019 (COVID-19) is
important to decipher mechanisms of host responses and interpret disease pathogenesis …

Exploring the utility of NK cells in COVID-19

X Deng, H Terunuma, M Nieda - Biomedicines, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) can manifest as acute respiratory distress syndrome
and is associated with substantial morbidity and mortality. Extensive data now indicate that …

Coordinated Loss and Acquisition of NK Cell Surface Markers Accompanied by Generalized Cytokine Dysregulation in COVID-19

MO Ustiuzhanina, JD Vavilova, AA Boyko… - International Journal of …, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, is accompanied
by a dysregulated immune response. In particular, NK cells, involved in the antiviral …

Are NKT cells a useful predictor of COVID-19 severity?

HF Koay, NA Gherardin, THO Nguyen, W Zhang… - Immunity, 2022 - cell.com
The article by (Kreutmair et al., 2021), published online with May 9, 2021 issue of Immunity,
delineated COVID-19-related immune signatures between mild and severe COVID-19 …