Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2

R Yan, Y Zhang, Y Li, F Ye, Y Guo, L Xia, X Zhong… - Cell research, 2021 - nature.com
Dear Editor, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a
severe threat to global health. 1 The spike (S) protein on the surface of SARS-CoV-2 exploits …

The SARS-CoV-2 spike protein: balancing stability and infectivity

I Berger, C Schaffitzel - Cell research, 2020 - nature.com
SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts
to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its …

Structure and mutations of SARS-CoV-2 spike protein: a focused overview

R Mehra, KP Kepp - ACS Infectious Diseases, 2021 - ACS Publications
The spike protein (S-protein) of SARS-CoV-2, the protein that enables the virus to infect
human cells, is the basis for many vaccines and a hotspot of concerning virus evolution …

[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2

MM Hatmal, W Alshaer, MAI Al-Hatamleh, M Hatmal… - Cells, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …

Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection

L Guo, W Bi, X Wang, W Xu, R Yan, Y Zhang, K Zhao… - Cell Research, 2021 - nature.com
Dear Editor, Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in a severe global pandemic. Following …

The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and …

M Murae, Y Shimizu, Y Yamamoto, A Kobayashi… - Biochemical and …, 2022 - Elsevier
Viral spike proteins play important roles in the viral entry process, facilitating attachment to
cellular receptors and fusion of the viral envelope with the cell membrane. Severe acute …

Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism

H Othman, Z Bouslama, JT Brandenburg… - Biochemical and …, 2020 - Elsevier
The spread of COVID-19 caused by the SARS-CoV-2 outbreak has been growing since its
first identification in December 2019. The publishing of the first SARS-CoV-2 genome made …

Functional importance of the D614G mutation in the SARS-CoV-2 spike protein

CB Jackson, L Zhang, M Farzan, H Choe - Biochemical and Biophysical …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus
which binds its cellular receptor angiotensin-converting enzyme 2 (ACE2) and enters hosts …

Gene of the month: the 2019-nCoV/SARS-CoV-2 novel coronavirus spike protein

TS Pillay - Journal of clinical pathology, 2020 - jcp.bmj.com
The year 2020 has seen a major and sustained outbreak of a novel betacoronavirus (severe
acute respiratory syndrome (SARS)-coronavirus (CoV)-2) infection that causes fever, severe …

Millisecond dynamic of SARS‐CoV‐2 spike and its interaction with ACE2 receptor and small extracellular vesicles

K Lim, G Nishide, T Yoshida… - Journal of …, 2021 - Wiley Online Library
Abstract SARS‐CoV‐2 spike protein (S) binds to human angiotensin‐converting enzyme 2
(hACE2), allowing virus to dock on cell membrane follow by viral entry. Here, we use high …