Fusion oncogenes are prevalent in several pediatric cancers, yet little is known about the
specific associations between age and phenotype. We observed that fusion oncogenes …

Chimeric transcription factors are a hallmark of human leukemia, but the molecular
mechanisms by which they block differentiation and promote aberrant self-renewal remain …

Pediatric acute myeloid leukemia expressing the ETO2:: GLIS2 fusion oncogene is
associated with dismal prognosis. Previous studies have shown that ETO2:: GLIS2 can …

This review aims to provide an overview of the current knowledge of the genetic lesions
driving pediatric acute myeloid leukemia (AML), emerging biological concepts, and …

Background Structural chromosomal rearrangements that lead to expressed fusion genes
are a hallmark of acute lymphoblastic leukemia (ALL). In this study, we performed …

Leukemias are heterogeneous diseases characterized by aberrant hematopoietic stem and
progenitor cells (HSPCs). Oncogenic fusion genes and proteins, produced via gross …

The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in
infants and early childhood and is associated with dismal outcome. Here, we demonstrate …

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion
gene landscape in a consecutive series of 195 paediatric B-cell precursor acute …

Acute myelogenous leukemias (AMLs) are genetically heterogeneous and characterized by
chromosomal rearrangements that produce fusion proteins with aberrant transcriptional …

The leukemia-associated fusion proteins share several structural or functional similarities,
suggesting that they may impart a leukemic phenotype through common modes of …