[PDF][PDF] Gene targeting in hemostasis. Hepsin

Q Wu - Front Biosci, 2001 - article.imrpress.com
Introduction 3. Hepsin cDNA and gene structures 3.1. Cloning of hepsin cDNA 3.2. Hepsin
gene structure 3.3. The promoter sequence of the mouse hepsin gene. 4. Hepsin protein 4.1 …

Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease.

Q Wu, D Yu, J Post, M Halks-Miller… - The Journal of …, 1998 - Am Soc Clin Investig
Hepsin is a type II transmembrane serine protease highly expressed on the surface of
hepatocytes. The physiological function of hepsin is not known, although in vitro studies …

Mice deficient in hepsin, a serine protease, exhibit normal embryogenesis and unchanged hepatocyte regeneration ability

IS Yu, HJ Chen, YSE Lee, PH Huang… - Thrombosis and …, 2000 - thieme-connect.com
Hepsin, a liver-enriched novel serine protease, has been implicated in participating with
normal cell growth, embryogenesis, and blood coagulation pathway. To study its function in …

Complete nucleotide sequence, origin of isoform and functional characterization of the mouse hepsin gene

S Kawamura, S Kurachi, Y Deyashiki… - European journal of …, 1999 - Wiley Online Library
Hepsin, a type‐II membrane‐associated serine protease, has been implicated in cell growth
and developement as well as possible initiation of blood coagulation. Here, we report on the …

Decreased expressions of hepsin in human hepatocellular carcinomas

CH Chen, KY Su, MH Tao, SW Lin, YH Su… - Liver …, 2006 - Wiley Online Library
Background/Aims: Hepsin is a type II transmembrane protein predominantly expressed in
the liver and has been implicated in participation in blood coagulation pathway and …

[PDF][PDF] Serine protease hepsin regulates hepatocyte size and hemodynamic retention of tumor cells by hepatocyte growth factor signaling in mice

YC Hsu, HP Huang, IS Yu, KY Su, SR Lin, WC Lin… - …, 2012 - Wiley Online Library
The liver architecture plays an important role in maintaining hemodynamic balance, but the
mechanisms that underlie this role are not fully understood. Hepsin, a type II transmembrane …

Identification and characterization of hepsin/-TM, a non-transmembrane hepsin isoform

Y Li, Z Yu, X Zhao, SH Shen - Biochimica et Biophysica Acta (BBA)-Gene …, 2005 - Elsevier
Type II transmembrane serine proteases (TTSPs), including hepsin, are a new class of cell
surface catalytic enzymes. In the present study, a non-transmembrane isoform of hepsin …

Autoactivation and calpain-1-mediated shedding of hepsin in human hepatoma cells

L Wang, C Zhang, S Sun, Y Chen, Y Hu… - Biochemical …, 2019 - portlandpress.com
Hepsin is a transmembrane serine protease implicated in many biological processes,
including hepatocyte growth, urinary protein secretion, auditory nerve development, and …

Hepsin colocalizes with desmosomes and induces progression of ovarian cancer in a mouse model

J Miao, D Mu, B Ergel, R Singavarapu… - … journal of cancer, 2008 - Wiley Online Library
Hepsin is a serine protease that is widely expressed in different tissues and cell types, most
prominently in the normal liver and kidney. Overexpression of hepsin has been associated …

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture

JA Xuan, D Schneider, P Toy, R Lin, A Newton, Y Zhu… - Cancer research, 2006 - AACR
Hepsin is a type II transmembrane serine protease that is expressed in normal liver, and at
lower levels in kidney, pancreas, and testis. Several studies have shown that hepsin mRNA …