Genetic contributions to suicidal thoughts and behaviors

E DiBlasi, J Kang, AR Docherty - Psychological medicine, 2021 - cambridge.org
Suicidal ideation, suicide attempt (SA) and suicide are significantly heritable phenotypes.
However, the extent to which these phenotypes share genetic architecture is unclear. This …

Genome‐wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early‐onset, major depression

GS Zubenko, BS Maher, HB Hughes III… - American Journal of …, 2004 - Wiley Online Library
We previously described the results of a genomewide linkage survey for genetic loci that
influenced the development of unipolar mood disorders in 81 families identified by …

Polygenic risk scores for neuropsychiatric, inflammatory, and cardio‐metabolic traits highlight possible genetic overlap with suicide attempt and treatment‐emergent …

G Fanelli, M Sokolowski, D Wasserman… - American Journal of …, 2022 - Wiley Online Library
Suicide is the second cause of death among youths. Genetics may contribute to suicidal
phenotypes and their co‐occurrence in other neuropsychiatric and medical conditions. Our …

Genetic liability to suicide attempt, suicide death, and psychiatric and substance use disorders on the risk for suicide attempt and suicide death: a Swedish national …

KS Kendler, H Ohlsson, EK Mościcki… - Psychological …, 2023 - cambridge.org
Background How does genetic liability to suicide attempt (SA), suicide death (SD), major
depression (MD), bipolar disorder (BD), schizophrenia (SZ), alcohol use disorder (AUD) …

Polygenic associations of neurodevelopmental genes in suicide attempt

M Sokolowski, J Wasserman, D Wasserman - Molecular psychiatry, 2016 - nature.com
The risk for suicidal behavior (SB) is elevated in schizophrenia (SCZ), bipolar disorder
(BPD) and major depressive disorder (MDD), but also occurs in subjects without psychiatric …

[HTML][HTML] Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population

I Otsuka, M Akiyama, O Shirakawa, S Okazaki… - …, 2019 - nature.com
Suicide is a significant public health problem worldwide, and several Asian countries
including Japan have relatively high suicide rates on a world scale. Twin, family, and …

Exploring the genetic overlap of suicide‐related behaviors and substance use disorders

SMC Colbert, AS Hatoum, A Shabalin… - American Journal of …, 2021 - Wiley Online Library
Suicide‐related behaviors are heterogeneous and transdiagnostic, and may demonstrate
varying levels of genetic overlap with different substance use disorders (SUDs). We used …

[HTML][HTML] Probing the genome to understand suicide

R Uher, N Perroud - American journal of psychiatry, 2010 - Am Psychiatric Assoc
Suicidal behavior, including completed and attempted suicide, is among the most tragic
events psychiatrists encounter in their practice and requires separate attention in diagnosis …

Genome-wide association study of suicide attempts in mood disorder patients

RH Perlis, J Huang, S Purcell, M Fava… - American Journal of …, 2010 - Am Psychiatric Assoc
Objective: Family and twin studies suggest that liability for suicide attempts is heritable and
distinct from mood disorder susceptibility. The authors therefore examined the association …

[HTML][HTML] Polygenic risk for suicide attempt is associated with lifetime suicide attempt in US soldiers independent of parental risk

MB Stein, S Jain, S Papini, L Campbell-Sills… - Journal of affective …, 2024 - Elsevier
Background Suicide is a leading cause of death worldwide. Whereas some studies have
suggested that a direct measure of common genetic liability for suicide attempts (SA) …