7. GENOME-WIDE ASSOCIATION STUDIES OF SUICIDAL THOUGHTS AND BEHAVIORS: AN UPDATE FROM THE PSYCHIATRIC GENOMICS CONSORTIUM …

S Colbert, D Ruderfer, A Docherty, N Mullins… - European …, 2023 - Elsevier
Background Suicidal thoughts and behaviors, specifically suicidal ideation (SI), suicide
attempt (SA) and suicide death (SD), are substantially heritable, with twin and family studies …

What is the future of suicide genetics?

S Mirza, GR Fries - Brazilian Journal of Psychiatry, 2023 - SciELO Brasil
Since the heritability of suicidal behaviors was established decades ago, investigators have
sought to understand the precise molecular mechanisms which might drive familial …

Suicidal ideation and planning among Mexican adolescents are associated with depression polygenic risk scores

GA Martinez‐Levy, AI Campos… - American Journal of …, 2021 - Wiley Online Library
Suicide is a major public health problem in Mexico and around the world. Genetic
predisposition for major depressive disorder (MDD) has been associated with increased risk …

The genetic basis for suicidal behavior

P Courtet - Psychiatric Times, 2005 - go.gale.com
Suicide persists as a major public health problem in all industrialized countries. More than
90% of people who commit suicide suffered from a psychiatric disorder, mostly a mood …

Ethical concerns relating to genetic risk scores for suicide

A Docherty, B Kious, T Brown, L Francis… - American Journal of …, 2021 - Wiley Online Library
Genome‐wide association studies (GWAS) provide valuable information in research
contexts regarding genomic changes that contribute to risks for complex psychiatric …

Genome-wide association study of suicide death and polygenic prediction of clinical antecedents

AR Docherty, AA Shabalin, E DiBlasi… - American journal of …, 2020 - Am Psychiatric Assoc
Objective: Death by suicide is a highly preventable yet growing worldwide health crisis. To
date, there has been a lack of adequately powered genomic studies of suicide, with no …

Ancestry and different rates of suicide and homicide in European countries: A study with population-level data

KN Fountoulakis, X Gonda - Journal of affective disorders, 2018 - Elsevier
Introduction There are large differences in suicide rates across Europe. The current study
investigated the relationship of suicide and homicide rates in different countries of Europe …

Psychosocial moderators of polygenic risk for suicidal ideation: Results from a 7-year population-based, prospective cohort study of US veterans

PJ Na, F De Angelis, B Nichter, FR Wendt… - Molecular …, 2022 - nature.com
Polygenic risk scores (PRS) may help inform the etiology of suicidal thoughts and behaviors.
In this study, we evaluated whether a suicidality PRS derived from a large genome-wide …

Genome-wide association study of suicidal behaviour severity in mood disorders

CC Zai, C Fabbri, GM Hosang, RS Zhang… - The World Journal of …, 2021 - Taylor & Francis
Objective Suicide is a major public health problem and it has a prominent genetic
component. We performed a genome-wide association study (GWAS) of suicidal behaviour …

GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors

AR Docherty, N Mullins… - American journal of …, 2023 - Am Psychiatric Assoc
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-
scale genome-wide association studies (GWASs) recently discovered and cross-validated …