The advent of antibiotics in the early twentieth century catalyzed a medical revolution,
drastically reducing mortality due to bacterial infections. Along with numerous other …

The discovery and development of antibacterial drugs in the twentieth century were major
scientific and medical achievements that have had profound benefits for human society …

Highlights•The threat of growing antimicrobial resistance urgently requires new 'silver
bullets'.•Traditional approaches to antibiotic discovery are failing to produce new antibiotics.• …

New antibiotics are necessary to treat microbial pathogens that are becoming increasingly
resistant to available treatment. Despite the medical need, the number of newly approved …

The discovery of drugs used to combat infectious diseases is in the process of constant
change to address the ever-worsening problem of antibiotic resistance in pathogens and a …

Antibiotics are an essential part of modern medicine. The emergence of antibiotic‐resistant
mutants among bacteria is seemingly inevitable, and results, within a few decades, in …

Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time,
little progress has been made in discovering new antibacterial drugs to combat resistant …

Importance of the field: Antibiotics have existed in the environment for millennia, but it has
only been in the past 80 years that humans have used them systematically to treat infections …

We are facing a potential catastrophe of untreatable bacterial infections, driven by the
inexorable rise of extensively drug-resistant bacteria, coupled with a market failure of …

An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …