During development and throughout adult life, macrophages derived from hematopoietic
progenitors are seeded throughout the body, initially in the absence of inflammatory and …

Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and
immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive …

The important role of macrophages in host defense against a variety of pathogens has long
been recognized and has been documented and reviewed in numerous publications …

Macrophages are essential components of mammalian tissues. Although historically known
mainly for their function in host defense and the clearance of apoptotic cells, macrophages …

Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result
of the specialization of tissue macrophages in particular microenvironments. Circulating …

The term 'macrophage'encompasses tissue cells that typically share dependence on the
same transcriptional regulatory pathways (eg the transcription factor PU. 1) and growth …

Macrophages are large mononuclear phagocytes that represent the major differentiated
elements of the mononuclear phagocytic system. They arise from distinct progenitors in the …

Macrophages are present in all vertebrate tissues, from mid-gestation throughout life,
constituting a widely dispersed organ system. They promote homeostasis by responding to …

Macrophages inhabit all major organs, and are capable of adapting their functions to meet
the needs of their home tissues. The recent recognition that tissue macrophages derive from …

Macrophages are a diverse phenotype of professional phagocytic cells derived from bone-
marrow precursors and parent monocytes in the peripheral blood. They are essential for the …