Background Fragile X syndrome and tuberous sclerosis are genetic syndromes that both
have a high rate of comorbidity with autism spectrum disorder (ASD). Several lines of …

Fragile X syndrome (FXS) is the most common single gene (FMR1) disorder affecting
cognitive and behavioral function in humans. This syndrome is characterized by a cluster of …

Fragile X syndrome (FXS) is a monogenic mental retardation syndrome that frequently
includes autism. The Fmr1‐knockout (Fmr1‐KO) mouse, like FXS‐affected individuals, lacks …

Despite the pronounced neurological deficits associated with mental retardation and autism,
the degree to which neocortical circuit function is altered remains unknown. Here, we study …

Restricted and repetitive behaviors, and a pronounced preference for behavioral and
environmental consistency, are distinctive characteristics of autism spectrum disorder (ASD) …

Abstract Background Fragile X syndrome (FXS) is the leading inherited monogenic cause of
intellectual disability and autism spectrum disorder. Executive function (EF), necessary for …

Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual
disability, sensory hypersensitivity, and high incidences of autism spectrum disorders and …

Background Cortical hyperexcitability due to abnormal fast-spiking inhibitory interneuron
function has been documented in fmr1 KO mice, a mouse model of the fragile X syndrome …

Fragile X is the most common monogenic disorder associated with intellectual disability (ID)
and autism spectrum disorders (ASD). Additionally, many patients are afflicted with …

Attention deficit is one of the most prominent and disabling symptoms in Fragile X syndrome
(FXS). Hypersensitivity to sensory stimuli contributes to attention difficulties by overwhelming …