[PDF][PDF] An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Y Liu, WT Soh, J Kishikawa, M Hirose, EE Nakayama… - Cell, 2021 - cell.com
Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein
prevent SARS-CoV-2 infection. However, the effects of antibodies against other spike …

[PDF][PDF] Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein

AC Walls, YJ Park, MA Tortorici, A Wall, AT McGuire… - Cell, 2020 - cell.com
The emergence of SARS-CoV-2 has resulted in> 90,000 infections and> 3,000 deaths.
Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of …

[HTML][HTML] SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies

Y Yang, L Du - Signal transduction and targeted therapy, 2021 - nature.com
A recent paper published in Science describes the detection of IgG antibody responses in
individuals infected by severe acute respiratory syndrome coronavirus (SARS-CoV-2). The …

[HTML][HTML] SARS-CoV-2 spike protein: flexibility as a new target for fighting infection

CL Pierri - Signal Transduction and Targeted Therapy, 2020 - nature.com
The spike protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
crucial for the infection because it mediates the virus entry into human host-cells, through …

[HTML][HTML] Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

C Yi, X Sun, J Ye, L Ding, M Liu, Z Yang, X Lu… - Cellular & molecular …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus
SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein …

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

X Chi, R Yan, J Zhang, G Zhang, Y Zhang, M Hao… - Science, 2020 - science.org
Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) could be guided by the distribution of epitopes, not only on the receptor binding …

[PDF][PDF] Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B. 1.1. 7 variant

C Graham, J Seow, I Huettner, H Khan, N Kouphou… - Immunity, 2021 - cell.com
Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2
on host cells is essential for viral entry. RBD is the dominant target for neutralizing …

D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

J Hu, CL He, QZ Gao, GJ Zhang, XX Cao, QX Long… - BioRxiv, 2020 - biorxiv.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein that mediates SARS-CoV-2 …

[HTML][HTML] Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies

M Yuan, H Liu, NC Wu, IA Wilson - Biochemical and biophysical research …, 2021 - Elsevier
Immediately from the outset of the COVID-19 pandemic, researchers from diverse
biomedical and biological disciplines have united to study the novel pandemic virus, SARS …

[HTML][HTML] A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein

C Kim, DK Ryu, J Lee, YI Kim, JM Seo, YG Kim… - Nature …, 2021 - nature.com
Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal …