Molecular and cellular mechanisms of pulmonary fibrosis

NW Todd, IG Luzina, SP Atamas - Fibrogenesis & tissue repair, 2012 - Springer
Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Pulmonary fibrosis: cellular and molecular events

MS Razzaque, T Taguchi - Pathology international, 2003 - Wiley Online Library
Connective tissue remodeling of the interstitium is an important feature of chronic lung
diseases encompassing interstitial inflammatory changes and subsequent pulmonary …

Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets

JC Hewlett, JA Kropski, TS Blackwell - Matrix Biology, 2018 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …

Immune mechanisms in pulmonary fibrosis

S Kolahian, IE Fernandez, O Eickelberg… - American journal of …, 2016 - atsjournals.org
Pulmonary fibrosis, particularly idiopathic pulmonary fibrosis, represents a chronic and
progressive disease with high mortality and limited therapeutic options. Excessive …

Integrating mechanisms of pulmonary fibrosis

TA Wynn - Journal of Experimental Medicine, 2011 - rupress.org
Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …

Mechanisms of pulmonary fibrosis

VJ Thannickal, GB Toews, ES White… - Annu. Rev …, 2004 - annualreviews.org
Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less
well-understood host repair responses. Both inflammation and repair involve the …

Macrophages in lung fibrosis

T Ogawa, S Shichino, S Ueha… - International …, 2021 - academic.oup.com
Pulmonary fibrosis (PF) is a disease in which excessive extracellular matrix (ECM)
accumulation occurs in the lungs, which induces thickening of the alveolar walls, ultimately …

Molecular mechanisms of and possible treatment strategies for idiopathic pulmonary fibrosis

M Gharaee-Kermani, SH Phan - Current pharmaceutical design, 2005 - ingentaconnect.com
Pulmonary fibrosis is characterized by lung inflammation and abnormal tissue repair,
resulting in the replacement of normal functional tissue with an abnormal accumulation of …

Idiopathic pulmonary fibrosis: new insights in its pathogenesis

A Pardo, M Selman - The international journal of biochemistry & cell biology, 2002 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a unique type of chronic fibrosing lung disease of
unknown etiology. The sequence of the pathogenic mechanisms is unknown, but the …

Idiopathic pulmonary fibrosis: from epithelial injury to biomarkers-insights from the bench side

M Kolb, K Borensztajn, B Crestani, M Kolb - Respiration, 2014 - karger.com
Idiopathic pulmonary fibrosis (IPF) is the most frequent fibrotic diffuse parenchymal lung
disease. Its prognosis is devastating:> 50% of the patients die within 3 years after diagnosis …