[HTML][HTML] mRNA vaccines for COVID-19: what, why and how
JW Park, PNP Lagniton, Y Liu… - International journal of …, 2021 - ncbi.nlm.nih.gov
Abstract The Coronavirus disease-19 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …
respiratory syndrome coronavirus-2 (SARS-CoV-2), has impacted human lives in the most …
Lipid nanoparticle (LNP) enables mRNA delivery for cancer therapy
Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …
[HTML][HTML] RNA vaccines: a suitable platform for tackling emerging pandemics?
JB Sandbrink, RJ Shattock - Frontiers in immunology, 2020 - frontiersin.org
The COVID-19 pandemic demonstrates the ongoing threat of pandemics caused by novel,
previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine …
previously unrecognized, or mutated pathogens with high transmissibility. Currently, vaccine …
Delivery of synthetic mRNAs for tissue regeneration
H Steinle, J Weber, S Stoppelkamp… - Advanced drug delivery …, 2021 - Elsevier
In recent years, nucleic acid-based therapeutics have gained increasing importance as
novel treatment options for disease prevention and treatment. Synthetic messenger RNAs …
novel treatment options for disease prevention and treatment. Synthetic messenger RNAs …
[HTML][HTML] mRNA as a transformative technology for vaccine development to control infectious diseases
G Maruggi, C Zhang, J Li, JB Ulmer, D Yu - Molecular Therapy, 2019 - cell.com
In the last two decades, there has been growing interest in mRNA-based technology for the
development of prophylactic vaccines against infectious diseases. Technological …
development of prophylactic vaccines against infectious diseases. Technological …
[HTML][HTML] Deliver the promise: RNAs as a new class of molecular entities for therapy and vaccination
The concepts of developing RNAs as new molecular entities for therapies have arisen again
and again since the discoveries of antisense RNAs, direct RNA-protein interactions …
and again since the discoveries of antisense RNAs, direct RNA-protein interactions …
[HTML][HTML] The critical contribution of pseudouridine to mRNA COVID-19 vaccines
P Morais, H Adachi, YT Yu - Frontiers in cell and developmental …, 2021 - frontiersin.org
The current COVID-19 pandemic is a massive source of global disruption, having led so far
to two hundred million COVID-19 cases and more than four million deaths worldwide. It was …
to two hundred million COVID-19 cases and more than four million deaths worldwide. It was …
[HTML][HTML] Vaccine mRNA can be detected in blood at 15 days post-vaccination
TE Fertig, L Chitoiu, DS Marta, VS Ionescu… - Biomedicines, 2022 - mdpi.com
COVID-19 mRNA vaccines effectively reduce incidence of severe disease, hospitalisation
and death. The biodistribution and pharmacokinetics of the mRNA-containing lipid …
and death. The biodistribution and pharmacokinetics of the mRNA-containing lipid …
Evading innate immunity in nonviral mRNA delivery: don't shoot the messenger
J Devoldere, H Dewitte, SC De Smedt, K Remaut - Drug discovery today, 2016 - Elsevier
Highlights•We review the immune-related hurdles in mRNA-based non-immunogenic
applications.•We suggest some methods to reduce unwanted innate immune …
applications.•We suggest some methods to reduce unwanted innate immune …
[HTML][HTML] Perspectives on RNA vaccine candidates for COVID-19
P Borah, PK Deb, NA Al-Shar'i… - Frontiers in Molecular …, 2021 - frontiersin.org
With the current outbreak caused by SARS-CoV-2, vaccination is acclaimed as a public
health care priority. Rapid genetic sequencing of SARS-CoV-2 has triggered the scientific …
health care priority. Rapid genetic sequencing of SARS-CoV-2 has triggered the scientific …