Abstract The SARS-CoV-2 Omicron BA. 1 variant emerged in 2021 and has multiple
mutations in its spike protein. Here we show that the spike protein of Omicron has a higher …

Molnupiravir, a wide-spectrum antiviral that is currently in phase 2/3 clinical trials for the
treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as …

Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating
conditions for substantial evolutionary changes to the virus,. Here we describe a newly …

A white-knuckle ride of open COVID drug discovery Skip to main content Thank you for visiting
nature.com. You are using a browser version with limited support for CSS. To obtain the best …

Except remdesivir, no specific antivirals for SARS-CoV-2 infection are currently available.
Here, we characterize two small-molecule-compounds, named GRL-1720 and 5h …

Vaccines and antivirals are the classical weapons deployed to contain, prevent, and treat life-
threatening viral illnesses. Specifically, for SARS-CoV-2 infection, vaccines protect against …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019
has triggered an ongoing global pandemic of the severe pneumonia-like disease …

When COVID-19 spread around the globe this year, David Montefiori wondered how the
deadly virus behind the pandemic might be changing as it passed from person to person …

Abstract The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with more …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved variants with
substitutions in the spike receptor-binding domain (RBD) that affect its affinity for angiotensin …