Histone variant H3. 3 plays novel roles in development as compared to canonical H3
proteins and is the most commonly mutated histone protein of any kind in human disease …

Histone H3. 3 is a highly conserved histone H3 replacement variant in metazoans and has
been implicated in many important biological processes, including cell differentiation and …

Background The histone variant H3. 3 plays key roles in regulating chromatin states and
transcription. However, the role of endogenous H3. 3 in mammalian cells and during …

Abstract H3. 3, the most common replacement variant for histone H3, has emerged as an
important player in chromatin dynamics for controlling gene expression and genome …

H3. 3 is a histone variant that marks transcription start sites as well as telomeres and
heterochromatic sites on the genome. The presence of H3. 3 is thought to positively …

The histone H3 variant H3. 3, encoded by two genes H3-3A and H3-3B, can replace
canonical isoforms H3. 1 and H3. 2. H3. 3 is important in chromatin compaction, early …

H3. 3 is a highly conserved nonreplicative histone variant. H3. 3 is enriched in promoters
and enhancers of active genes, but it is also found within suppressed heterochromatin …

Histone proteins wrap around DNA to form nucleosomes, which further compact into the
higher-order structure of chromatin. In addition to the canonical histones, there are also …

The systematic mutation of histone 3 (H3) genes in model organisms has proven to be a
valuable tool to distinguish the functional role of histone residues. No system exists in …

A host of cancer types exhibit aberrant histone modifications. Recently, distinct and recurrent
mutations in a specific histone variant, histone H3. 3, have been implicated in a high …