During the past few years the results from molecular biological, biochemical, chemical,
physical and theoretical approaches expanded the knowledge about metallo-β-lactamases …

Class B β‐lactamases or metallo‐β‐lactamases (MBLs) require zinc ions to catalyse the
hydrolysis of β‐lactam antibiotics such as penicillins, cephalosporins, carbapenems, and …

In an effort to probe the role of the Zn (II) sites in metallo-β-lactamase L1, mononuclear metal
ion containing and heterobimetallic analogues of the enzyme were generated and …

We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based
screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen …

Bacterial resistance is compromising the use of β-lactam antibiotics including carbapenems.
The main resistance mechanism against β-lactams is hydrolysis of the β-lactam ring …

Metallo-β-lactamases are important as a major source of resistance of pathogenic bacteria
to the widely used β-lactam antibiotics. They show considerable diversity in terms of …

Metallo-β-lactamases (MβLs) are zinc-dependent enzymes able to hydrolyze and inactivate
most β-lactam antibiotics. The large diversity of active site structures and metal content …

The New Delhi Metallo-β-lactamase (NDM-1) was first reported in 2009 in a Swedish
patient. A recent study reported that Klebsiella pneumonia NDM-1 positive strain or …

ABSTRACT A clinical Escherichia coli isolate resistant to all β-lactams, including
carbapenems, expressed a novel metallo-β-lactamase (MBL), NDM-4, differing from NDM-1 …

Objectives Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-
lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been …