Understanding the structure and dynamics of the enzymes that mediate antibiotic resistance
of pathogenic bacteria will allow us to take steps to combat this increasingly serious public …

One strategy developed by bacteria to resist the action of β-lactam antibiotics is the
expression of metallo-β-lactamases. CphA from Aeromonas hydrophila is a member of a …

β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the
increasing emergence of resistance to them, developed by bacteria producing β-lactamase …

β-Lactamase evolution presents to the infectious disease community a major challenge in
the treatment of infections caused by multidrug-resistant gram-negative bacteria. Because …

β-Lactamase production is responsible for the appearance of a large number of pathogenic
bacterial strains exhibiting a high degree of resistance to β-lactam antibiotics. A large …

The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of
β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections …