Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma
H Ijichi, A Chytil, AE Gorska, ME Aakre… - The Journal of …, 2011 - Am Soc Clin Investig
Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is
characterized by an expanded stroma with marked fibrosis (desmoplasia). We previously …
characterized by an expanded stroma with marked fibrosis (desmoplasia). We previously …
Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell …
M Sano, H Ijichi, R Takahashi, K Miyabayashi… - Oncogenesis, 2019 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense stromal reaction
(desmoplasia). We have previously reported that mice with conditional Kras G12D mutation …
(desmoplasia). We have previously reported that mice with conditional Kras G12D mutation …
[HTML][HTML] CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging
malignancies. Desmoplasia and tumor-supporting inflammation are hallmarks of PDAC. The …
malignancies. Desmoplasia and tumor-supporting inflammation are hallmarks of PDAC. The …
Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis
MN Wente, MP Keane, MD Burdick, H Friess… - Cancer Letters, 2006 - Elsevier
A central feature of all solid tumor growth is the presence of neovascularization. The CXC
chemokines GRO-γ/CXCL3, ENA-78/CXCL5, and IL-8/CXCL8 have profound angiogenic …
chemokines GRO-γ/CXCL3, ENA-78/CXCL5, and IL-8/CXCL8 have profound angiogenic …
Small molecule antagonist of CXCR2 and CXCR1 inhibits tumor growth, angiogenesis, and metastasis in pancreatic cancer
Pancreatic cancer (PC) has a poor prognosis, and current therapeutic strategies are
ineffective in advanced diseases. We and others have shown the aberrant expression of …
ineffective in advanced diseases. We and others have shown the aberrant expression of …
Co-targeting of CXCR4 and hedgehog pathways disrupts tumor-stromal crosstalk and improves chemotherapeutic efficacy in pancreatic cancer
Pancreatic cancer (PC) remains a therapeutic challenge because of its intrinsic and extrinsic
chemoresistance mechanisms. Here, we report that CXC motif chemokine receptor 4 …
chemoresistance mechanisms. Here, we report that CXC motif chemokine receptor 4 …
CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase-and Akt kinase-mediated …
Recent evidence suggests a major role of tumor-stromal interactions in pancreatic cancer
pathobiology. The chemokine CXCL12 (stromal cell-derived factor 1 (SDF-1)), abundantly …
pathobiology. The chemokine CXCL12 (stromal cell-derived factor 1 (SDF-1)), abundantly …
[HTML][HTML] IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an abundant desmoplastic
reaction driven by pancreatic stellate cells (PSCs) that contributes to tumor progression …
reaction driven by pancreatic stellate cells (PSCs) that contributes to tumor progression …
CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis
Pancreatic ductal adenocarcinoma is an unsolved health problem with nearly 75% of
patients diagnosed with advanced disease and an overall 5-year survival rate near 5 …
patients diagnosed with advanced disease and an overall 5-year survival rate near 5 …
Chemokine receptor CXCR4 enhances proliferation in pancreatic cancer cells through AKT and ERK dependent pathways
X Shen, A Artinyan, D Jackson, RM Thomas, AM Lowy… - Pancreas, 2010 - journals.lww.com
Objectives: We previously detected CXCR4 expression in pancreatic intraepithelial
neoplasia (PanIN) tissues and demonstrated CXCR4-enhanced proliferation of PanIN cells …
neoplasia (PanIN) tissues and demonstrated CXCR4-enhanced proliferation of PanIN cells …