The neurotrophins represent a family of survival and differentiation factors that exert
profound effects in the central and peripheral nervous systems (1). Five neurotrophins, NGF …

Neurotrophin‐mediated cell survival and differentiation of vertebrate neurons is caused by
ligand‐specific binding to the Trk family of tyrosine kinase receptors. However, sites in the …

The study of structure–function relationships in the neurotrophin family has in recent years
increased our understanding of several important aspects of neurotrophin function. Site …

Neurotrophins regulate differentiation and survival of vertebrate neurons through binding to
members of the Trk family of receptor tyrosine kinases and to a common low affinity receptor …

Neurotrophins bind to two structurally unrelated receptors, the trk tyrosine kinases and the
neurotrophin receptor p75 NTR. Ligand activation of these two types of receptor can lead to …

We have exploited a battery of approaches to address several controversies that have
accompanied the expansion of the nerve growth factor (NCF) family of neurotrophic factors …

The neurotrophins mediate their effects through binding to two classes of receptors, a
tyrosine kinase receptor, member of the Trk family, and the low‐affinity neurotrophin …

Neurotrophins are a family of highly conserved proteins that affect the development and
maintenance of distinct neuronal populations. Neurotrophins exist in vivo as homodimers …

The Trk family of tyrosine-protein kinases, TrkA, TrkB, and TrkC, are the signaling receptors
that mediate the biological properties of the NGF family of neurotrophins. This family of …

Neurotrophins rely on Trk tyrosine kinase and p75 receptors for signal transduction.
Recently, other roles for these receptors have been identified. Many questions have been …