A general strategy for thesynthesis of highly substituted polycyclic aromatic and
heteroaromatic compounds has been developed. The new aromatic annulation is …

2.1. 1 Halogenation–coupling 2.1. 2 Metalation–halogenation–coupling 2.1. 3 Metalation–
transmetalation–coupling 2.1. 4 N-Arylation of heteroaromatics 2.1. 5 Examples of rapid …

Approaches to carbocyclic systems mimickingDiels-Alder chemistry, wherein a six-
membered ring is generated from two acyclic precursors in a single synthetic operation …

The thermal combination of cyclobutenone derivatives with heterosubstituted acetylenes
provides a regiocontrolled route to highly substituted aromatic com-pounds. Sir …

A brief review is provided of procedures developed in the author's laboratories which
enhance the value of aromatic synthons used in the synthesis of alicyclic target compounds …

The synthesis of three trisubstituted aryloxazolines, 7, 8, and 10, containing an o-methoxyl
group served as useful precursors to eight benzo-fused ring systems. In this fashion, novel …

A versatile method for the synthesis of complex, fused polycyclic aromatic systems in high
chemical yield is described. Construction is achieved using a general two-step synthetic …

A two-stage “tandem strategy” for the synthesis of indoles with a high level of substitution on
the six-membered ring is described. Benzannulation based on the reaction of …

Thermolysis of 1-cyano-4-methoxy-1-(4-methoxycarbonyl-4-vinyl) pentylbenzocyclobutene
(3), derived from methyl methylacetoacetate (7) in five steps, gave (±)-4aa-cyano-1, 2, 3, 4 …

4-Chloro-2, 3-disubstituted-2-cyclobutenones undergo palladium-catalyzed cross-coupling
with oxygen and sulfur heteroaryl tin reagents, and uponthermolysis at 100 C, good to high …