Nucleic acids are regarded as reliable biomarkers for the early diagnosis of various
diseases. By ingeniously combining a transduction hairpin (THP) with the toehold-mediated …

In this work, an intelligent multiregion linear DNA walker (MLDW) with a high walking rate
and a high amplification efficiency was explored for ultrasensitive detection of miRNA …

An isothermal, enzyme-free and ultrasensitive protocol for electrochemical detection of DNA
is proposed based on the ingenious combination of target catalyzed hairpin assembly and …

In this paper, a robust and highly integrated DNA bipedal walker based electrochemical
biosensor was designed on single nanoelectrodes for ultrasensitive miRNA-21 detection …

Herein, a long period liner DNA tandem (Lr-DNT) was intelligently designed as DNA track
for quadruped DNA walker (q-walker) to run in an orderly and efficient manner, which could …

In this work, a DNA three-way junction (TWJ) with multiple recognition regions was
intelligently engineered, which could be applied as an unconfined DNA walker with a rapid …

The development of simple, flexible, cost-effective and sensitive electrochemical methods for
protein analysis is of very importance for its potential application in disease diagnosis and …

Herein, an ultrasensitive electrochemical biosensor for microRNA-155 (miR-155) detection
based on the powerful catalytic and continuous walking signal amplification capability of 3D …

A bipedal molecular machine powered surface programmatic chain reaction was designed
for electrochemical signal amplification and highly sensitive electrochemical detection of …

Herein, by directly limiting the reaction space, an ingenious three-dimensional (3D) DNA
walker (IDW) with high walking efficiency is developed for rapid and sensitive detection of …