Anosmia in COVID-19: a bumpy road to establishing a cellular mechanism

K Bilinska, R Butowt - ACS chemical neuroscience, 2020 - ACS Publications
It has become clear since the pandemic broke out that SARS-CoV-2 virus causes reduction
of smell and taste in a significant fraction of COVID-19 patients. The olfactory dysfunction …

Mechanisms of SARS-CoV-2-associated anosmia

T Tsukahara, DH Brann, SR Datta - Physiological Reviews, 2023 - journals.physiology.org
Anosmia, the loss of the sense of smell, is one of the main neurological manifestations of
COVID-19. Although the SARS-CoV-2 virus targets the nasal olfactory epithelium, current …

Anosmia in COVID-19: underlying mechanisms and assessment of an olfactory route to brain infection

R Butowt, CS von Bartheld - The Neuroscientist, 2021 - journals.sagepub.com
In recent months it has emerged that the novel coronavirus—responsible for the COVID-19
pandemic—causes reduction of smell and taste in a large fraction of patients. The …

Mechanism of anosmia caused by symptoms of COVID-19 and emerging treatments

R Najafloo, J Majidi, A Asghari… - ACS Chemical …, 2021 - ACS Publications
The occurrence of anosmia, the loss or change in sense of smell, is one of the most common
symptoms of COVID-19 experienced by almost 53% of those affected. Several hypotheses …

COVID-19-related anosmia: the olfactory pathway hypothesis and early intervention

A Gori, F Leone, L Loffredo, BL Cinicola… - Frontiers in …, 2020 - frontiersin.org
Anosmia is a well-described symptom of Corona Virus Disease 2019 (COVID-19). Several
respiratory viruses are able to cause post-viral olfactory dysfunction, suggesting a …

Anosmia in COVID-19: mechanisms and significance

AY Han, L Mukdad, JL Long, IA Lopez - Chemical senses, 2020 - academic.oup.com
The global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a challenge for prevention due …

Mechanistic understanding of the olfactory neuroepithelium involvement leading to short-term anosmia in COVID-19 using the adverse outcome pathway framework

MA Shahbaz, F De Bernardi, A Alatalo, M Sachana… - Cells, 2022 - mdpi.com
Loss of the sense of smell (anosmia) has been included as a COVID-19 symptom by the
World Health Organization. The majority of patients recover the sense of smell within a few …

Proinflammatory cytokines in the olfactory mucosa result in COVID-19 induced anosmia

A Torabi, E Mohammadbagheri… - ACS chemical …, 2020 - ACS Publications
Studies have found increased rates of dysosmia in patients with Novel Coronavirus disease
2019 (COVID-19). However, the mechanism that causes olfactory loss is unknown. The …

[HTML][HTML] Revealing the mystery of persistent smell loss in Long COVID patients

JW Park, X Wang, RH Xu - International Journal of Biological …, 2022 - ncbi.nlm.nih.gov
COVID-19 is hopefully approaching its end in many countries as herd immunity develops
and weaker strains of SARS-CoV-2 dominate. However, a new concern occurs over the long …

Olfactory dysfunction in COVID-19: new insights into the underlying mechanisms

R Butowt, K Bilinska, CS von Bartheld - Trends in Neurosciences, 2023 - cell.com
The mechanisms of olfactory dysfunction in COVID-19 are still unclear. In this review, we
examine potential mechanisms that may explain why the sense of smell is lost or altered …