Epigenomic and other evidence for cannabis-induced aging contextualized in a synthetic epidemiologic overview of cannabinoid-related teratogenesis and …

AS Reece, GK Hulse - … Journal of Environmental Research and Public …, 2022 - mdpi.com
Background: Twelve separate streams of empirical data make a strong case for cannabis-
induced accelerated aging including hormonal, mitochondriopathic, cardiovascular …

Clinical epigenomic explanation of the epidemiology of cannabinoid genotoxicity manifesting as transgenerational teratogenesis, cancerogenesis and aging …

AS Reece, GK Hulse - … Journal of Environmental Research and Public …, 2023 - mdpi.com
As global interest in the therapeutic potential of cannabis and its' derivatives for the
management of selected diseases increases, it is increasingly imperative that the toxic …

Novel Insights into Potential Cannabis-Related Cancerogenesis from Recent Key Whole Epigenome Screen of Cannabis Dependence and Withdrawal …

AS Reece, GK Hulse - Genes, 2022 - mdpi.com
Whilst the cannabis-cancer link has been traditionally described as controversial recent
whole nation and whole continent studies have demonstrated that well documented …

Impacts of cannabinoid epigenetics on human development: reflections on Murphy et. al.'cannabinoid exposure and altered DNA methylation in rat and human sperm' …

AS Reece, GK Hulse - Epigenetics, 2019 - Taylor & Francis
Recent data from the Kollins lab ('Cannabinoid exposure and altered DNA methylation in rat
and human sperm'Epigenetics 2018; 13: 1208–1221) indicated epigenetic effects of …

Cannabis genotoxicity and cancer incidence: Highly concordant synthesis of European and USA datasets

AS Reece, GK Hulse - Cannabis Use, Neurobiology, Psychology, and …, 2023 - Elsevier
The reports of the epidemiologically causal involvement of cannabis in incident and
inheritable carcinogenesis in the USA, along with the explicated epidemiology of cannabis …

Perturbation of 3D nuclear architecture, epigenomic dysregulation and aging, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid …

AS Reece, GK Hulse - Frontiers in Psychiatry, 2023 - frontiersin.org
Much recent attention has been directed toward the spatial organization of the cell nucleus
and the manner in which three-dimensional topologically associated domains and …

[HTML][HTML] Cannabis, cannabidiol, cannabinoids, and multigenerational policy

AS Reece, GK Hulse, W Wang - Engineering, 2023 - Elsevier
While classical laboratory and animal data have long established cannabinoid genotoxicity,
it is only recently, with the application of modern analytical techniques, that the scale of …

Cannabis exposure as an interactive cardiovascular risk factor and accelerant of organismal ageing: a longitudinal study

AS Reece, A Norman, GK Hulse - BMJ open, 2016 - bmjopen.bmj.com
Objectives Many reports exist of the cardiovascular toxicity of smoked cannabis but none of
arterial stiffness measures or vascular age (VA). In view of its diverse toxicology, the …

Epidemiological overview of multidimensional chromosomal and genome toxicity of cannabis exposure in congenital anomalies and cancer development

AS Reece, GK Hulse - Scientific reports, 2021 - nature.com
Cannabis and cannabinoids are implicated in multiple genotoxic, epigenotoxic and
chromosomal-toxic mechanisms and interact with several morphogenic pathways, likely …

Epigenetic effects of cannabis exposure

H Szutorisz, YL Hurd - Biological psychiatry, 2016 - Elsevier
The past decade has witnessed a number of societal and political changes that have raised
critical questions about the long-term impact of marijuana (Cannabis sativa) that are …