Metronomic chemotherapy refers to the close, regular administration of comparatively low
doses of cytotoxic drugs, with minimal or no drug-free breaks, over prolonged periods. It is …

Prolonged, frequently administered low-dose metronomic chemotherapy (LDM) is being
explored (pre) clinically as a promising antiangiogenic antitumor strategy. Although …

Background Metronomic chemotherapy (MCT) refers to the chronic and equally spaced
administration of low doses of different chemotherapy drugs, without extended rest periods …

The administration of chemotherapy at reduced doses given at regular, frequent time
intervals, termed 'metronomic'chemotherapy, presents an alternative to standard maximal …

The survival benefits of traditional maximum tolerated dose (MTD) cytotoxic therapy have
been modest for the treatment of most types of metastatic malignancy and, moreover, often …

Metronomic antiangiogenic chemotherapy, the prolonged administration of relatively low
drug doses, at close regular intervals with no significant breaks, has been mainly studied at …

Low-dose metronomic (LDM) chemotherapy is emerging as an alternative or supplemental
dosing strategy to conventional maximum tolerated dose (MTD) chemotherapy. It is …

The introduction of the “maximum tolerated dose” in usual treatment protocols (and its
concomitant overt toxicity) made necessary the imposition of rest periods between cycles of …

Metronomic chemotherapy (MC) refers to the close administration of a chemotherapeutic
drug for a long time with no extended drug-free breaks. It was developed to overcome drug …

Metronomic (low-dose, long-term and frequently administered) chemotherapy has attracted
renewed interest for the past few years, in particular because of possible positive …