The trkB tyrosine protein kinase is a receptor for neurotrophin-4

R Klein, F Lamballe, S Bryant, M Barbacid - Neuron, 1992 - cell.com
Neurotrophin-4 is a novel member of the nerve growth factor family of neurotrophins recently
isolated from Xenopus and viper DNA. We now report that the Xenopus NT-4 protein(XNT4) …

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

R Klein, V Nanduri, S Jing, F Lamballe, P Tapley… - Cell, 1991 - cell.com
Summary trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that
encodes a receptor for nerve growth factor (NGF) and neurotrophin-3(NT-3). t&B expression …

The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells

P Tsoulfas, D Soppet, E Escandon, L Tessarollo… - Neuron, 1993 - cell.com
Members of the Trk tyrosine kinase family have recently been identified as functional
receptors of the NGF family of neurotrophins. Here we show the rat trkC locus to be complex …

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

NY Ip, CF Ibanez, SH Nye, J McClain… - Proceedings of the …, 1992 - National Acad Sciences
Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the
three members of the neurotrophin family known to exist in mammals. Recently, a fourth …

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

NY Ip, TN Stitt, P Tapley, R Klein, DJ Glass, J Fandl… - Neuron, 1993 - cell.com
We have exploited a battery of approaches to address several controversies that have
accompanied the expansion of the nerve growth factor (NCF) family of neurotrophic factors …

Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 bind to a single leucine-rich motif of TrkB

JM Windisch, R Marksteiner, ME Lang, B Auer… - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received May 23, 1995® abstract: TrkB is a member of the Trk family of
neurotrophin receptors. Its extracellular domain exhibits the same modular structure found in …

Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB

LR Berkemeier, JW Winslow, DR Kaplan, K Nikolics… - Neuron, 1991 - cell.com
In vertebrates, the formation and maintenance of neuronal connections are subject to
regulation by multiple target-derived, diffusible (neurotrophic) factors. Here we describe the …

Neurotrophic factors and their receptors

M Barbacid - Current opinion in cell biology, 1995 - Elsevier
Several new members of the nerve growth factor family of neurotrophins, which comprises
nerve growth factor itself, brain-derived neurotrophic factor and neurotrophins-3,-4 (also …

Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by TrkC (∗)

M Rydén, CF Ibánez - Journal of Biological Chemistry, 1996 - ASBMB
Neurotrophins regulate differentiation and survival of vertebrate neurons through binding to
members of the Trk family of receptor tyrosine kinases and to a common low affinity receptor …

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

SP Squinto, TN Stitt, TH Aldrich, S Davis, SM Blanco… - Cell, 1991 - cell.com
A variety of findings seem to functionally link brainderived neurotrophic factor (BDNF))'and
neurotrophin3 (NT-3), while distinguishing both of these factors from the third member of the …