A new era of GPCR structural and chemical biology

S Granier, B Kobilka - Nature chemical biology, 2012 - nature.com
G protein–coupled receptors (GPCRs) are versatile molecular machines that regulate the
majority of physiological responses to chemically diverse hormones and neurotransmitters …

The structure and function of G-protein-coupled receptors

DM Rosenbaum, SGF Rasmussen, BK Kobilka - Nature, 2009 - nature.com
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to
hormones, neurotransmitters and environmental stimulants, and so have great potential as …

Structural basis for G protein-coupled receptor activation

A Manglik, AC Kruse - Biochemistry, 2017 - ACS Publications
G protein-coupled receptors (GPCRs) are critical regulators of human physiology and make
up the largest single class of therapeutic drug targets. Although GPCRs regulate highly …

Molecular signatures of G-protein-coupled receptors

AJ Venkatakrishnan, X Deupi, G Lebon, CG Tate… - Nature, 2013 - nature.com
G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …

Structure and function of peptide-binding G protein-coupled receptors

F Wu, G Song, C de Graaf, RC Stevens - Journal of Molecular Biology, 2017 - Elsevier
G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and are
important human drug targets. Of the 826 human GPCRs, 118 of them recognize …

Structure-function of the G protein–coupled receptor superfamily

V Katritch, V Cherezov… - Annual review of …, 2013 - annualreviews.org
During the past few years, crystallography of G protein–coupled receptors (GPCRs) has
experienced exponential growth, resulting in the determination of the structures of 16 distinct …

[HTML][HTML] G protein-coupled receptors: the evolution of structural insight

SB Gacasan, DL Baker, AL Parrill - AIMS biophysics, 2017 - ncbi.nlm.nih.gov
G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins
that have gained relevance as biological targets for pharmaceutical drug design. Although …

Activation of G protein–coupled receptors

X Deupi, B Kobilka - Advances in protein chemistry, 2007 - Elsevier
G protein–coupled receptors (GPCRs) mediate responses to hormones and
neurotransmitters, as well as the senses of sight, smell, and taste. These remarkably …

[HTML][HTML] Structural studies of G protein-coupled receptors

D Zhang, Q Zhao, B Wu - Molecules and cells, 2015 - Elsevier
G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically
important membrane protein family that recognizes a variety of environmental stimuli, and …

Conformational basis of G protein-coupled receptor signaling versatility

LM Wingler, RJ Lefkowitz - Trends in cell biology, 2020 - cell.com
G protein-coupled receptors (GPCRs) are privileged structural scaffolds in biology that have
the versatility to regulate diverse physiological processes. Interestingly, many GPCR ligands …