In this review, we have selected several outstanding studies from the American Journal of
Respiratory and Critical Care Medicine (AJRCCM), the American Journal of Respiratory Cell …

Cystic fibrosis (CF) research and case reports were robust in the year 2018. This report
summarizes publications related the multisystem effects of CF, pulmonary exacerbations …

Major advances in our understanding of cystic fibrosis (CF) lung disease and its treatment
have materialized over the last decades. Targeting therapies to the major pathophysiologic …

The clinical face of cystic fibrosis (CF) has significantly changed over the 25 years since its
basic genetic defect was discovered (1). Increasing numbers of patients are diagnosed at …

Introduction: Cystic fibrosis (CF) outcomes and survival have improved over the last century
primarily due to advancements in antibiotics, nutritional, and pulmonary therapies …

Clinical outcomes and management of cystic fibrosis (CF) have undergone startling and
dramatic advances in the last two decades. These improvements can be linked to the …

Since the discovery of the gene encoding the cystic fibrosis transmembrane regulator
protein (CFTR) in 1989, rapid expansion in our understanding of the basic defect has …

Cystic fibrosis (CF) is an autosomal recessive disease that was previously a fatal pediatric
disease with no treatment; however, due to scientific advancements, the median age of …

What have we learned from real-world experience about highly effective CFTR modulation
and its impact on the lives of patients with cystic fibrosis? In 2019, the triple combination …

With the 2019 breakthrough in the development of highly effective modulator therapy
providing unprecedented clinical benefits for over 90% of patients with cystic fibrosis who …