An RBD bispecific antibody effectively neutralizes a SARS-CoV-2 Omicron variant

M Yuan, Y Zhu, G Liu, Y Wang, G Wang, G Zhang… - One Health …, 2023 - Springer
Potent neutralizing antibodies (nAbs) against SARS-CoV-2 are a promising therapeutic
against the ongoing COVID-19 pandemic. However, the continuous emergence of …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

[HTML][HTML] Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - bioRxiv, 2021 - ncbi.nlm.nih.gov
The emergence of SARS-CoV-2 variants that threaten the efficacy of existing vaccines and
therapeutic antibodies underscores the urgent need for new antibody-based tools that …

Combating the SARS-CoV-2 Omicron (BA. 1) and BA. 2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Y Wang, X Zhang, Y Ma, Y Wang, W Zhan, Q Zheng… - Cell Discovery, 2022 - nature.com
The highly mutated and transmissible Omicron (BA. 1) and its more contagious lineage BA.
2 have provoked serious concerns over their decreased sensitivity to the current COVID-19 …

VH3-53/66-Class RBD-Specific Human Monoclonal Antibody iB20 Displays Cross-Neutralizing Activity against Emerging SARS-CoV-2 Lineages

SV Kulemzin, MV Sergeeva, KO Baranov… - Journal of Personalized …, 2022 - mdpi.com
Immune evasion of SARS-CoV-2 undermines current strategies tocounteract the pandemic,
with the efficacy of therapeutic virus-neutralizing monoclonal antibodies (nAbs) being …

Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern

H Cho, KK Gonzales-Wartz, D Huang, M Yuan… - Science translational …, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
of concern threatens the efficacy of existing vaccines and therapeutic antibodies and …

A synthetic bispecific antibody capable of neutralizing SARS-CoV-2 Delta and Omicron

TZ Yuan, C Lucas, VS Monteiro, A Iwasaki, ML Yang… - bioRxiv, 2022 - biorxiv.org
Bispecific antibodies have emerged as a promising strategy for curtailing severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) immune escape. This brief report …

[PDF][PDF] Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA. 1/BA. 1.1/BA. 2/BA. 3

M Huang, L Wu, A Zheng, Y Xie, Q He, X Rong, P Han… - Immunity, 2022 - cell.com
SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies
and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal …

Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2

Q Zhang, B Ju, J Ge, JFW Chan, L Cheng… - Nature …, 2021 - nature.com
Neutralizing antibodies (nAbs) to SARS-CoV-2 hold powerful potentials for clinical
interventions against COVID-19 disease. However, their common genetic and biologic …

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved …

Z Liu, W Xu, Z Chen, W Fu, W Zhan, Y Gao… - Protein & …, 2022 - academic.oup.com
New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to
find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design …