[HTML][HTML] Identification of an IGHV3-53-Encoded RBD-Targeting Cross-Neutralizing Antibody from an Early COVID-19 Convalescent

Y Hu, C Hu, S Wang, L Ren, Y Hao, Z Wang, Y Liu… - Pathogens, 2024 - mdpi.com
Since November 2021, Omicron has emerged as the dominant severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variant, and its sublineages continue to appear one …

Neutralization or enhancement of SARS-CoV-2 infection by a monoclonal antibody targeting a specific epitope in the spike receptor-binding domain

GC Lai, TL Chao, SY Lin, HC Kao, YM Tsai, DC Lu… - Antiviral research, 2022 - Elsevier
Neutralizing antibodies (NAbs) are believed to be promising prophylactic and therapeutic
treatment against the coronavirus disease 2019 (COVID-19), which is caused by severe …

[HTML][HTML] Antibody cocktail exhibits broad neutralization activity against SARS-CoV-2 and SARS-CoV-2 variants

Y Qu, X Zhang, M Wang, L Sun, Y Jiang, C Li, W Wu… - Virologica Sinica, 2021 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated multiple
variants resistant to therapeutic antibodies. In this study, 12 high-affinity antibodies were …

Structural insights for neutralization of Omicron variants BA. 1, BA. 2, BA. 4, and BA. 5 by a broadly neutralizing SARS-CoV-2 antibody

S Kumar, A Patel, L Lai, C Chakravarthy… - Science …, 2022 - science.org
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from
single B cells of the COVID-19–recovered individuals in India who experienced ancestral …

[HTML][HTML] A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants

X Duan, R Shi, P Liu, Q Huang, F Wang… - … and Targeted Therapy, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants
threatens efforts to contain the coronavirus disease 2019 (COVID-19) pandemic. Omicron …

[HTML][HTML] Neutralizing antibodies for the prevention and treatment of COVID-19

L Du, Y Yang, X Zhang - Cellular & molecular immunology, 2021 - nature.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initiates the infection
process by binding to the viral cellular receptor angiotensin-converting enzyme 2 through …

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking

L Liu, RG Casner, Y Guo, Q Wang, S Iketani, JFW Chan… - bioRxiv, 2023 - biorxiv.org
SUMMARY SARS-CoV-2 continues to evolve and evade most existing neutralizing
antibodies, including all clinically authorized antibodies. We have isolated and …

Comparative assessment of the binding and neutralisation activity of bispecific antibodies against SARS-CoV-2 variants

AQ Dean, CB Stauft, JD Twomey, J Tan… - Antibody …, 2023 - academic.oup.com
Background Neutralising antibodies against SARS-CoV-2 are a vital component in the fight
against COVID-19 pandemic, having the potential of both therapeutic and prophylactic …

A potent SARS-CoV-2 antibody neutralizes Omicron variant by disassembling the spike trimer

W Zhan, X Tian, X Zhang, S Xing, W Song, Q Liu… - bioRxiv, 2022 - biorxiv.org
The continuous emergence of novel SARS-CoV-2 variants poses new challenges to the fight
against the COVID-19 pandemic. The newly emerging Omicron strain caused serious …

Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccination

Y Chen, L Zhu, W Huang, X Tong, H Wu… - Emerging Microbes & …, 2021 - Taylor & Francis
Global concerns arose as the emerged and rapidly spreading SARS-CoV-2 variants might
escape host immunity induced by vaccination. In this study, a heterologous prime-boost …