Here we describe a microphysiological system that replicates the functional unit of the living
human lung. This human “breathing lung-on-a-chip” microdevice provides unique …

The lung is the primary respiratory organ of the human body and has a complicated and
precise tissue structure. It comprises conductive airways formed by the trachea, bronchi and …

The intertwined relationship between structure and function has been key to understanding
human organ physiology and disease pathogenesis. An organ-on-a-chip (organ chip) is a …

Abstract'Organs-on-chips' are microengineered biomimetic systems containing microfluidic
channels lined by living human cells, which replicate key functional units of living organs to …

We report a lung-on-a-chip array that mimics the pulmonary parenchymal environment,
including the thin alveolar barrier and the three-dimensional cyclic strain induced by …

Preclinical drug development studies currently rely on costly and time-consuming animal
testing because existing cell culture models fail to recapitulate complex, organ-level disease …

Development of organoids and microfluidic on-chip models has enabled studies of organ-
level disease pathophysiologies in vitro. However, current lung-on-a-chip platforms are …

Organs-on-chips are microfluidic cell culture devices created using microchip manufacturing
techniques that contain hollow microchannels lined by living cells, which recreate …

The air-blood barrier with its complex architecture and dynamic environment is difficult to
mimic in vitro. Lung-on-a-chips enable mimicking the breathing movements using a thin …

Here, we present a physiologically relevant model of the human pulmonary alveoli. This
alveolar lung-on-a-chip platform is composed of a three-dimensional porous hydrogel made …